Studies on the mechanism of the lung toxicity of paraquat: Comparison of tissue distribution and some biochemical parameters in rats and rabbits
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2010, Progress in Brain ResearchCitation Excerpt :Accordingly, in vitro mechanistic experiments showed that both compounds produce significant oxidative stress after administration (Chun et al., 2001). However, paraquat has long been known to undergo redox cycling with generation of reactive oxygen species (ROS) (Fisher et al., 1973; Ilett et al., 1974). Furthermore, it has been directly demonstrated that paraquat does not act by direct inhibition of complex I (Richardson et al., 2005).
Nifedipine nanoparticle agglomeration as a dry powder aerosol formulation strategy
2009, International Journal of PharmaceuticsMitochondria are a major source of paraquat-induced reactive oxygen species production in the brain
2007, Journal of Biological ChemistryCitation Excerpt :Rat Brain Mitochondria Are a Major Cellular Component Involved in PQ2+-induced ROS Generation—The mechanism of ROS generation by redox cycling of PQ2+ has been widely studied in both in vivo and in vitro systems. These studies point out the involvement of several mitochondrial (30), microsomal (31, 32), and cytosolic (23, 33) enzymes in ROS production by PQ2+. Several studies have suggested the involvement of mitochondria in PQ2+-induced O¯·2 generation.
- 1
Present Address: Department of Pharmacology, University of Western Australia, Nedlands, 6009, Western Australia.
- 2
Supported by NHLI Fellowship FO2 HE51972-01 and by Hoffman-La Roche, Nutley, New Jersey.
- 3
Present address: Reston-Georgetown Medical Center, Hunter's Woods Plaza, Reston, Virginia.