Decreased pneumotoxicity of deuterated 3-methylindole: Bioactivation requires methyl CH bond breakage☆
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Surface grafting of a π-conjugated amino-ferrocifen drug
2013, Journal of Electroanalytical ChemistryCitation Excerpt :These molecules combine endocrine modulating properties and cytotoxicity, such effects being namely related to the ability of (1) to undergo an intramolecular base-promoted electron transfer between the oxidized ferrocene center and the aminophenyl moiety. The oxidation sequence ultimately yields the biologically active form, viz., a quinone imine responsible for the cytotoxic activity [29–34]. In that context, (1) showed a strong antiproliferative effect on breast cancer cells (MBA-MB231), with a IC50 value of 0.8 μM, making this compound even more cytotoxic than the analog ferrocenyl phenol (IC50 = 1.13 μM) [20].
The importance of sample preparation and storage in glutathione analysis
1993, Analytical Biochemistry<sup>1</sup>L<inf>a</inf> transitions of jet-cooled 3-methylindole
1992, Chemical Physics Letters3-Methylindole-induced splenotoxicity: Functional analysis of immune parameters and lymphocyte phenotyping by flow cytometry
1991, Toxicology and Applied Pharmacology
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This work was supported by Grant HL13645 from the U.S. Public Health Service, National Institutes of Health.
Copyright © 1987 Published by Elsevier Inc.