Comparative pharmacokinetics of 67Ga and 59Fe in humans
References (26)
- et al.
J. Clin. Chim. Acta
(1972) Semin. nucl. Med.
(1978)- et al.
Int. J. nucl. Med. Biol.
(1981) - et al.
Int. J. nucl. Med. Biol.
(1979) - et al.
Semin. nucl. Med.
(1975) - et al.
Int. J. nucl. Med. Biol.
(1979) - et al.
Int. J. nucl. Med. Biol.
(1980) - et al.
J. Pharmacokinet. Biopharm.
(1974) - et al.
Cancer Res.
(1974) - et al.
J. nucl. Med.
(1969)
Cancer Res.
J. nucl. Med.
J. nucl. Med.
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2023, Materials and DesignEffect of morphology and (Sn, Cr) doping on in vitro antiproliferation properties of hydrothermally synthesized 1D GaOOH nanostructures
2021, Journal of Science: Advanced Materials and DevicesCitation Excerpt :This dissimilarity slows down or numbs metabolic activities under the bio-availability of Ga3+ that replaces Fe3+ [22]. Ga3+ breaks the respiration process due to its non-redox active nature and thus cannot bind with heme in the blood, which makes Ga3+ anti-proliferative to cancer cells and a few bacterial cells [23,24]. Apart from the above-mentioned advantages, Ga3+ has also been proven to have an irrevocable affinity towards certain tissues, especially transferrin expressed in proliferating tissues, reforming bones, and many other tumor-related tissues [25–27].
<sup>67</sup>Ga as a biosensor of iron needs in different organs: Study performed on male and female rats subjected to iron deficiency and exercise
2017, Journal of Trace Elements in Medicine and BiologyThe therapeutic potential of iron-targeting gallium compounds in human disease: From basic research to clinical application
2017, Pharmacological ResearchCitation Excerpt :Despite gallium’s binding to Tf in the circulation and its cellular uptake by the TfR, gallium’s pharmacokinetics is different from that of iron. A comparison of 67Ga-citrate and 59Fe citrate distribution in the body showed that after its intravenous injection in healthy individuals, the elimination rate constant for 67Ga citrate was 50-fold slower than that for 59Fe citrate and that 59Fe was cleared from the blood at a more rapid rate than 67Ga [24]. The distribution of 59Fe was largely confined to hematopoietic tissues for hemoglobin production.
Gallium and its competing roles with iron in biological systems
2016, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :The volume of distribution of 67Ga in the body is approximately 6 times that of 59Fe as the latter metal is largely confined to hematopoietic tissues for hemoglobin production. The uptake of 59Fe by the sacrum, liver, spleen, and heart follows classically described ferrokinetics with uptake progressively declining after achieving a peak uptake at 24 h following injection [45,46]. In contrast 67Ga rapidly accumulates in the same tissue in the first 24 h following injection but then progressively increases in these tissues with time [45].