Changes in some hepatic enzyme activities related to phase II drug metabolism in male and female rats as a function of age

doi:10.1016/0047-6374(88)90084-X

Mechanisms of Ageing and Development

Volume 44, Issue 2, August 1988, Pages 115-125

https://doi.org/10.1016/0047-6374(88)90084-X Get rights and content

Abstract

Changes in activity of some hepatic enzymes related to UDP-glucuronic acid conjugation (UDP-glucose dehydrogenase and UDP-glucuronyl transferase) and g enzymes (glutathione reductase and glutathione peroxidase) were investigated in male and female Wistar rats as a function of age.

UDP-glucose dehydrogenase activity showed a decrease in the ageing period in both sexes (26.4% and 37.7% in males and females respectively), and no sex found in all the ages studied. The UDP-glucuronyl transferase (using p-nitrophenol as substrate) showed an age-dependent decrease in its activi increase for female rats. A sex difference (male values were higher than female values) was observed only in young rats (1 and 3 months old).

Glutathione peroxidase activity increased with age in both sexes (the activity found in male and female old rats was about 162% and 149% respectively t adulthood), and a marked difference was observed between sexes in young and old rats (57.8% and 45.4% higher in females in young and old rats respectiv glutathione reductase activity showed a decrease in the ageing (39% in male and 35.5% in female) and the highest levels during lifetime was found in ma

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Changes in some hepatic enzyme activities related to phase II drug metabolism in male and female rats as a function of age

Abstract

Arch. Biochem. Biophys.

Biochem. Biophys. Res. Commun.

J. Biol. Chem.

J. Biol. Chem.

Mech. Ageing Dev.

Clin. Biochem.

Biochem. Pharmacol.

Musca domestica. Mech. Ageing Dev.

Mech. Ageing Dev.

Biochim. Biophys. Acta

Biochim. Biophys. Acta

Drug disposition in old age

N. Engl. J. Med.

Pharmacology and ageing

J. Am. Geriatr. Soc.

Clinical pharmacokinetics

N. Engl. J. Med.

Age-related changes in drug disposition

Pharmacol. Rev.

Renal excretion of drugs in the elderly

Lancet

The influence on drug metabolism: implications for drug dosage

Med. J. Aust.

Effect of age and sex on disposition of demethyldiazepan formed from its clorazepate

Psychopharmacology

Sex differences in the response of rats to drugs affecting GABAergic transmission

Life Sci.

Hepatic microsomal monooxygenase and azoreductase activities in aging Fischer 344 rats

Age-dependent alterations in rat liver microsomal NADPH-cytochrome c (P-450) reductase during aging

Age

Senescent changes in rodent hepatic epoxide metabolism

Chem. Biol. Interact.

Techniques for the characterization of UDP glucuronyl transferase, glucose 6 phosphatase and other tightly bound microsomal enzymes