Paper12-HETE inhibits the binding of PGH2/TxA2 receptor ligands in human platelets
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2021, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Depending on the stimulus studied, 12-HETE has been shown to have promoting and suppressing effects on platelet activation.48 Notably 12-HETE interacts with the TXA2 receptor and inhibits TXA2-induced platelet aggregation.49,50 Platelets and TXA2 receptor have been identified as key factors required for inflammation in AERD.51,52
Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies
2019, Progress in Lipid ResearchOxygenation of polyunsaturated fatty acids and oxidative stress within blood platelets
2018, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :Second, they can be esterified within platelet phospholipids, which may limit interactions with their specific receptors [53]. Although the lipoxygenase end-products are clearly inhibitors of TxA2-induced platelet aggregation, especially the mono-hydroxy derivatives 12-HETE and 14-HDoHE, their interactions with TxA2 receptor is only putative [54,55]. However, the observation that the (R) stereoisomers appear more potent than the (S) ones, e.g. 13(R)-HODE vs 13(S)-HODE, 12(R)-HETE vs 12(S)-HETE, 12(R)-HHT vs 12(S)-HHT [47], 9(R),16(S)-diOH-18:3 vs 9(S),16(S)-diOH-18:3 [36], and 10(R),17(S)-diOH-22:6 vs the 10(S),17(S)-diOH isomer named PDX [44,56], suggests that the 3D conformation of these hydroxylated derivatives might be important for antagonizing the TxA2 receptor.
Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS
2018, Journal of Lipid ResearchCitation Excerpt :Considering that 12(R)-HETE is synthesized by cytochrome P450 in the ocular system (27) and by 12(R)-LOX in the epidermis and tonsils (28, 29), we hypothesize that low levels of serum 12(R)-HETE are formed nonenzymatically. The role of 12(S)-HETE in platelet biology is not fully understood, with studies reporting both activation (30–32) and inhibition (33, 34) of platelet aggregation. The 12-HETE has been implicated in the pathophysiology of cancer, arteriosclerosis, and diabetes (26).
Functional fluxolipidomics of polyunsaturated fatty acids and oxygenated metabolites in the blood vessel compartment
2015, Progress in Lipid ResearchCitation Excerpt :Those two molecules are also able to modulate platelet aggregation; 12-HpETE is an activator of both the release of ArA through cPLA2 and its oxygenation into prostanoids by stimulating the cyclooxygenase activity [22]. In contrast, the accumulation of 12-HETE may inhibit the reactivity of TxA2 [23], at the level of its receptor site [24]. The kinetics of 12-LOX is slower than that of COX, but more stable with time, meaning that the early 12-LOX activity might potentiate the TxA2-dependent aggregation whereas the later 12-LOX activity might inhibit it, as do PGD2 and the late PGE2.
Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis
2015, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids