Calcium antagonists isradipine and nimodipine suppress cocaine and morphine intravenous self-administration in drug-naive mice
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Cited by (107)
L-type calcium channel regulation of dopamine activity in the ventral tegmental area to nucleus accumbens pathway: Implications for substance use, mood disorders and co-morbidities
2023, NeuropharmacologyCitation Excerpt :Furthermore, LTCC blockers have also been shown to mediate the behavioral effects of other substance, such as morphine and nicotine, as reflected by LTCC inhibitor attenuation of CPP and drug self-administration (Kuzmin et al., 1992; Biala and Langwinski, 1996; Biała, 2003; Biala and Budzynska, 2006). In rodent studies using intravenous (i.v.) cocaine self-administration, the LTCC blockers isradipine and nimodipine have been shown to attenuate the reinforcing effects of both cocaine and morphine (Kuzmin et al., 1992). In contrast, work from our lab revealed that VTA specific administration of the LTCC inhibitor, isradipine, does not affect I.V. cocaine self-administration (Addy et al., 2018).
Usage of L-type calcium channel blockers to suppress drug reward and memory driving addiction: Past, present, and future
2022, NeuropharmacologyCitation Excerpt :The first animal studies reporting the potential involvement of LTCCs in the dopaminergic system in the action of addictive drugs came from studies demonstrating that dihydropyridine LTCC blockers (nimodipine and isradipine) suppress cocaine-induced DA release in the ventral striatum and locomotor stimulation in rats, while other types of LTCC blockers (verapamil and diltiazem) were ineffective (Pani et al., 1990a, 1990b). Subsequently, a number of studies have reported that systemic administration of LTCC blockers inhibits acquisition of drug-induced conditioned place preference (CPP) (Biala and Langwinski, 1996; Pani et al., 1991; Pucilowski et al., 1993, 1995), a form of Pavlovian learning where distinct contextual cues of the conditioning box are paired with drug exposure, and also suppresses acquisition of operant responding (self-administration) for cocaine and morphine (Kuzmin et al., 1992). How can these observations be explained by the role of LTCCs in the dopaminergic system?
Calcium channel antagonists suppress cross-tolerance to the anxiogenic effects of d-amphetamine and nicotine in the mouse elevated plus maze test
2008, Progress in Neuro-Psychopharmacology and Biological Psychiatry