Ventrolateral striatal dopamine depletions impair feeding and food handling in rats

doi:10.1016/0091-3057(93)90174-R

Pharmacology Biochemistry and Behavior

Volume 44, Issue 3, March 1993, Pages 605-610

https://doi.org/10.1016/0091-3057(93)90174-R Get rights and content

Abstract

The present study was conducted to characterize the changes in feeding behavior produced by localized depletion of dopamine (DA) in the nucleus accumbens and subregions of the neostriatum in the rat. Food-deprived rats were given at least 2 weeks of training, which consisted of being placed in a Plexiglas box and being given 15–18 g of food for a 30-min session. After the training period, rats received bilateral injections of the neurotoxic agent 6-hydroxydopamine (6-OHDA) into the nucleus accumbens, ventromedial striatum, or ventrolateral striatum. Observations were made in 30-min tests on days 3 and 7 after surgery, and measures were obtained for total food intake, time spent feeding, rate of feeding, and forepaw usage during feeding. The ventrolateral striatum was the only site at which dopamine depletion altered aspects of food intake. Rats with ventrolateral striatal DA depletion had reductions in food intake, decreases in the rate of feeding, and impaired forepaw usage during feeding. Time spent feeding was not significantly affected by DA depletion. Water consumption was significantly reduced by DA depletions in the ventrolateral striatum but not by depletions at other sites. These results indicate that ventrolateral striatal DA depletions decrease food intake by impairment of motor functions necessary for the performance of feeding behavior.

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Ventrolateral striatal dopamine depletions impair feeding and food handling in rats

Abstract

Brain Res.

Neuropharmacology

Behav. Brain Res.

Brain Res.

Behav. Brain Res.

Life Sci.

Behav. Brain Res.

Brain Res.

Neuroscience

Behav. Brain Res.

Brain Res.

Neuroscience

Neuropharmacology

Life Sci.

Microstimulation of the primate neostriatum. 2. Somatotopic organization of striatal microexcitable zones and their relation to neuronal response properties

J. Neurophysiol.

Dopaminergic regulation of feeding behavior: I. Differential effects of haloperidol microinjection in three striatal subregions

Psychobiology

Pharmacological manipulation of food and water intake

Dopamine in the lateral caudate-putamen of the rat is essential for somatosensory orientation

Behav. Neurosci.

The origin of thalamic inputs to the “hand” representation in the primary motor cortex

J. Neurosci.

Vacuous jaw movements and feeding deficits in rats with ventrolateral striatal dopamine depletions: Possible relation to parkinsonian symptoms

J. Neurosci.

Cholinergic stimulation of the ventrolateral striatum elicits mouth movements in rats: Pharmacological and regional specificity

Psychopharmacology (Berl.)

Induction of oral stereotypy following amphetamine microinjection into a discrete subregion of the striatum

Psychopharmacology (Berl.)