ArticleSome behavioural and neurochemical aspects of subacute (±)3,4-methylenedioxymethamphetamine administration in rats
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Differential effects of MDMA and cocaine on inhibitory avoidance and object recognition tests in rodents
2017, Neurobiology of Learning and MemoryIncreased anxiety and impaired spatial memory in young adult rats following adolescent exposure to methylone
2016, Pharmacology Biochemistry and BehaviorCitation Excerpt :This conclusion was based on decreased ambulation and increased elimination of fecal boluses and occupation of corners in the open field. The effect on ambulation was the opposite to that typifying adult rats when tested in the drugged state (López-Arnau et al., 2012), as can also occur with other drugs such as MDMA (Kolyaduke and Hughes, 2013; McNamara et al., 1995). However, the effect on fecal boluses was only typical of males and rats treated during early adolescence.
Central amygdala nicotinic and 5-HT1A receptors mediate the reversal effect of nicotine and MDMA on morphine-induced amnesia
2014, NeuroscienceCitation Excerpt :On the other hand, our results also showed that intra-CeA injection of a higher dose of MDMA (2-μg/rat) alone significantly decreased memory retrieval. In contrast, McNamara et al. (1995) proposed that MDMA can elevate locomotor activity without any impact on step-down passive avoidance learning. MDMA-associated cognitive dysfunctions have been well documented in basic and clinical studies (McCann et al., 1999; Camarasa et al., 2008).
Behavioral and neurochemical effects of repeated MDMA administration during late adolescence in the rat
2014, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Acute MDMA induces 5-HT release from the dorsal raphe nucleus (Bradberry et al., 1990), known to be a major source of 5-HT for the forebrain (Azmitia and Segal, 1978; Jacobs and Azmitia, 1992; Koch and Galloway, 1997), although the subsequent effects of various repeated (experimenter-administered) dosing regimens have produced differential alterations of the 5-HT system. A commonly used neurotoxic dosing regimen (4 injections per day for 1–2 days) depletes monoamine neurotransmitter levels in adult rats, specifically 5-HT and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA), as well as 5-HT markers such as 5-HT transporters (SERT) and receptors, with varying degrees of recovery (Gurtman et al., 2002; McNamara et al., 1995; Perrine et al., 2010). These ‘neurotoxic’ effects are observed in a number of 5-HT projection fields although neuroanatomical specificity is seen with greater depletion in cortical and limbic areas and less in thalamic structures (Battaglia et al., 1991).
Rapid development of semistarvation-induced hyperactivity in Dark Agouti rats. Excessive wheel running and effect of 3,4-methylenedioxymethamphetamine (MDMA)
2013, AppetiteCitation Excerpt :For this reason, these rats have been used as a genetic model of high activity in exercise-related studies (Koch et al., 2005) and have also been presented as a high-anxiety model in studies of anxiogenic behaviour (Mechan et al., 2002). Because acute administration of MDMA causes hyperactivity in DA rats (Callaway et al., 1990; Green, Mechan, Elliott, O’Shea, & Colado, 2003; McNamara, Kelly, & Leonard, 1995; Rodsiri et al., 2011; Spanos & Yamamoto, 1989) that can last for 10–28 days (e.g. Balogh et al., 2004; Walker et al., 2007), the present study characterised ABA/SIH in DA rats and ascertain whether the long-term effect of MDMA-induced hyperactivity would facilitate its development. To examine the long-term effects on activity reported in previous literature, drug administration was performed by a single injection of 12.5 mg/kg and the behavioural experiment began 1 week after that administration.