ArticleModulation of plus-maze behaviour in mice by the preferential D3-receptor agonist 7-OH-DPAT
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2004, Brain ResearchCitation Excerpt :There is much evidence from several laboratories indicating that risk assessment behaviors are typically elicited in response to novelty [49], defensive/withdrawal [79,108], predator scent [6], defensive burying [78], predator exposure [120], as well as in the EPM [23,113]. Anxiolytic drugs commonly reduce protected stretch attend in favor of unprotected stretch attend (approach) in the open arms of the EPM [90,91,92,94]; enhance cautious approach toward the rat stimulus in the closed alley situation in the mouse defense test battery [44,45,46,48,117]; and reduce avoidance and protected stretch attend in the rat exposure test [119,120]. Recent pharmacological reports have also shown that several neurotransmitter systems within the mouse right hemisphere IL vmPFC influence protected risk assessment activity in the EPM [113,115,116] and in the mouse defense test battery.
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