Original articleDemonstration that circulating human blood cells have no detectable alpha1-adrenergic receptors by radioligand binding analysis
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Autonomic regulation of T-lymphocytes: Implications in cardiovascular disease
2019, Pharmacological ResearchCitation Excerpt :Early studies utilized α agonists and found no changes in T-lymphocyte proliferation [79], which served as proof for lack of α-ARs on T-lymphocytes. Additionally, there was a reported absence of α1-AR mRNA in PBMCs [80], while more recent studies have shown that α1-AR mRNA is present in PBMCs by in-situ hybridization [81]. Heilig et al. found that H3-thymidine incorporation was reduced in a dose-dependent fashion to the α1-AR agonist phenylephrine, with this relationship disappearing with the α-AR antagonist phentolamine [82].
Impaired PARP activity in response to the β-adrenergic receptor agonist isoproterenol
2018, Toxicology in VitroCitation Excerpt :However, whether or not α-ARs are expressed in immune cells is still a controversy. Early reports attribute α1-AR activity to platelet contamination (Casale and Kaliner, 1984) but a recent study characterized α1-AR subtype expression on human monocytes and macrophages (Grisanti et al., 2011). Interestingly, neuroendocrine mediators, such as glucocorticoids and cytokines, enhance α1-AR expression in the immune system (Heijnen et al., 1996; Rouppe Voort et al., 1999).
Changes in the expression of α<inf>1B</inf>-adrenoceptor in peripheral mononuclear cells correlates with blood pressure and plasmatic homocysteine
2017, Biomedicine and PharmacotherapyAutonomic regulation of cellular immune function
2014, Autonomic Neuroscience: Basic and ClinicalModulation of Immune Cell Function by α1-Adrenergic Receptor Activation
2011, Current Topics in MembranesCitation Excerpt :Plasma cells secrete these specific antibodies, which bind the unique pathogenic antigens on cells to initiate the complement cascade as well as targeting these antigenic cells for phagocytes. While there are varied reports of α1-AR expression on isolated PMBCs, a mixed cell preparation which contains B cells, there are no reports to suggest α1-AR expression specifically on B cells (Casale & Kaliner, 1984; Rouppe van der Voort et al., 2000; Tayebati et al., 2000). The spleen is an important immune system organ responsible for removing old red blood cells, maintaining a blood reserve, recycling elemental iron, synthesizing antibodies as well as retaining half the body's monocytes, which allows them to move into injured tissues for differentiation into DCs and macrophages.
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Present address: Dept. of Internal Medicine, U. of Iowa Hospitals and Clinics, Iowa City, IA 52242.