A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

doi:10.1016/0092-8674(81)90018-0

Cell

Volume 66, Issue 3, 9 August 1991, Pages 555-561

https://doi.org/10.1016/0092-8674(81)90018-0 Get rights and content

Abstract

The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR. This regulation is conferred through a specific cis element in the CRBPII promoter that contains five nearly perfect tandem repeats of the sequence AGGTCA spaced by a single nucleotide. The discovery of this new RX response element provides a means for distinguishing between the two retinoid receptor systems and suggests that an RXR-mediated pathway exists for modulating vitamin A metabolism.

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Cell

ArticleA direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

Abstract

Neuron

J. Biol. Chem.

Cell

Trends Genet

J. Biol. Chem.

J. Biol. Chem.

Cell

Cell

Transport and storage of vitamin A

Science

Identification of a retinoic acid responsive element in the retinoic acid receptor β gene

Nature

Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: implications for regulation of retinoic acid synthesis

Mol. Cell. Biol.

The steroid and thyroid hormone receptor superfamily

Science

Identification of a receptor for the morphogen retinoic acid

Nature

Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein

Article
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR