Cell
Volume 59, Issue 3, 3 November 1989, Pages 411-419
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Review
Neural and developmental actions of lithium: A unifying hypothesis

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  • Cited by (924)

    • Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase

      2022, Journal of Biological Chemistry
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      Interestingly, treatment of cells with the inositol-depleting drugs lithium or VPA results in AMPK activation and IP6K1 nuclear translocation (Fig. 6). Lithium and VPA are known inhibitors of the inositol biosynthetic pathway; lithium uncompetitively inhibits inositol monophosphatase, and VPA indirectly inhibits MIPS by an unknown mechanism (11, 50, 51). The current findings suggest that, in addition to these previously described mechanisms, lithium and VPA may induce inositol depletion by activating AMPK and increasing PA production.

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