Cell
Volume 59, Issue 3, 3 November 1989, Pages 411-419
ReviewNeural and developmental actions of lithium: A unifying hypothesis
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Cited by (924)
Lithium engages autophagy for neuroprotection and neuroplasticity: Translational evidence for therapy
2023, Neuroscience and Biobehavioral ReviewsRegulations of myo-inositol homeostasis: Mechanisms, implications, and perspectives
2023, Advances in Biological RegulationPhosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase
2022, Journal of Biological ChemistryCitation Excerpt :Interestingly, treatment of cells with the inositol-depleting drugs lithium or VPA results in AMPK activation and IP6K1 nuclear translocation (Fig. 6). Lithium and VPA are known inhibitors of the inositol biosynthetic pathway; lithium uncompetitively inhibits inositol monophosphatase, and VPA indirectly inhibits MIPS by an unknown mechanism (11, 50, 51). The current findings suggest that, in addition to these previously described mechanisms, lithium and VPA may induce inositol depletion by activating AMPK and increasing PA production.
Sphingolipid depletion suppresses UPR activation and promotes galactose hypersensitivity in yeast models of classic galactosemia
2022, Biochimica et Biophysica Acta - Molecular Basis of Disease
Copyright © 1989 Published by Elsevier Inc.