Cell
Volume 75, Issue 4, 19 November 1993, Pages 671-680
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Article
Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

https://doi.org/10.1016/0092-8674(93)90488-CGet rights and content

Abstract

Transforming growth factor β (TGFβ) and activin each bind to pairs of membrane proteins, known as receptor types I and II, that associate to form a signaling complex. We report that TSR-I and ActR-I, two human transmembrane serine/threonine kinases distantly related to TGFβ and activin type II receptors, act as type I receptors for these factors. TSR-I is a type I receptor shared by TGFβ and activin, whereas ActR-I is an activin type I receptor. ActR-I, but not TSR-I, signals a particular transcriptional response in concert with activin type II receptors. The results indicate that type I receptors are transmembrane protein kinases that associate with type II receptors to generate diverse heteromeric serine/threonine kinase complexes of different signaling capacities.

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