Cell
Articlep53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
References (81)
- et al.
cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF
Cell
(1988) - et al.
The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
Cell
(1989) - et al.
Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
Cell
(1989) - et al.
WAF1, a potential mediator of p53 tumor suppression
Cell
(1993) - et al.
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
Cell
(1993) - et al.
Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+
Cell
(1988) - et al.
Cyclin A is required for the onset of DNA replication in mammalian fibroblasts
Cell
(1991) - et al.
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
Cell
(1992) - et al.
DNA repair endonuclease activity during synchronous proliferation of diploid human fibroblasts
Mutat. Res.
(1990) - et al.
G1 arrest and cell cycledependent clastogenesis in UV-irradiated human fibroblasts
Mutat. Res.
(1994)
The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in cell-free system
Cell
A proliferation of cyclins
Trends Cell Biol.
Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast
Cell
Colony-Stimulating Factor 1 regulates novel cyclins during the G1 phase of the cell cycle
Cell
Conditional inhibition of transformation and cell proliferation by a temperature-sensitive mutant of p53
Cell
Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis
Cell
Cyclin-dependent kinases: a new cell cycle motif?
Trends Cell Biol.
Doing the right thing: feedback control and p53
Curr. Opin. Cell Biol.
An essential G1 function for cyclin-like proteins in yeast
Cell
Mammalian G1 cyclins
Cell
Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2
Cell
Population explosion in the cyclin family
Curr. Biol.
Human D-type cyclin
Cell
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
Cell
Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
Cell
Cyclin A is required in S phase in normal epithelial cells
Biochem. Biophys. Res. Commun.
Cyclin D1 is a nuclear protein required for cell cycle progression in G1
Genes Dev.
Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization
Cancer Res.
The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression
Activation of human cyclin-dependent kinases in vitro
Mol. Biol. Cell
Association of human cyclin E with a periodic G1-S phase protein kinase
Science
Altered regulation of G1 cyclins in senescent human diploid fibroblasts: Accumulation of inactive cyclin D1/Cdk2 and cyclin E/Cdk complexes
Wild-type p53 activates transcription in vitro
Nature
Mammalian genes coordinately regulated by growth arrest signals and DNA damaging agents
Mol. Cell. Biol.
A transcriptionally active DNA-binding site for human p53 protein complexes
Mol. Cell. Biol.
Ataxia-telangiectasia: an interdisciplinary approach to pathogenesis
Medicine
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
Nature
Telomeres, telomerase and senescence
Bioessays
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
EMBO J.
Inhibition of Cdk2 activity in vivo by an associated 20K regulatory subunit
Nature
Cited by (1481)
ETS transcription factors: Multifaceted players from cancer progression to tumor immunity
2023, Biochimica et Biophysica Acta - Reviews on CancerComparative analysis of mouse embryonic palatal mesenchymal cells isolated by two primary culture methods
2022, Tissue and CellCitation Excerpt :P16 can block cell cycle progression by inhibiting cyclin D–CDK4/6 complexes, thereby activating Rb to inhibit E2F transcriptional effects (Sherr et al., 2002). p53 can directly activate p21 (el-Deiry et al., 1993; Dulic et al. 1994) and PAI-1 (Kortlever et al., 2006) to mediate cell cycle arrest and senescence (Wu et al., 2018). Combined with other experiments in our study, we selected P5 to confirmed cells senescence.
CDK Inhibitors in Normal and Malignant Cells
2022, Encyclopedia of Cell Biology: Volume 1-6, Second EditionOn the role of p53 in the cellular response to aneuploidy
2021, Cell ReportsCitation Excerpt :Micronuclei formed infrequently and at a similar frequency in MPS1i-treated RPE1, HCT116, and mCOs (Figure S1E), suggesting that micronuclei formation was not a source of DNA damage in our study. We next determined the effect of acute aneuploidy induction on p53 and the CDK inhibitor CDKN1A (p21), a well-studied direct transcriptional target of p53 that controls cell cycle progression (Dulić et al., 1994; el-Deiry et al., 1993). p53 is known to be regulated predominantly by posttranslational modifications that affect its stability or nuclear accumulation (Haupt et al., 1997; Kruse and Gu, 2009; Oren, 1999).
- †
Present address: Centre de Biochimie, Centre National de la Recherche Scientifique, Faculté des Sciences, Université de Nice, Parc Valrose, 06108 Nice Cedex 2, France.