Elsevier

The Lancet

Volume 337, Issue 8736, 2 February 1991, Pages 268-269
The Lancet

SHORT REPORTS
Interaction of citrus juices with felodipine and nifedipine

https://doi.org/10.1016/0140-6736(91)90872-MGet rights and content

Abstract

Six men with borderline hypertension took felodipine 5 mg with water, grapefruit juice, or orange juice. The mean felodipine bioavailability with grapefruit juice was 284 (range 164-469)% of that with water. The dehydrofelodipine/felodipine AUC ratio was lower, diastolic blood pressure lower, and heart rate higher with grapefruit juice than with water. Vasodilatation-related side-effects were more frequent. Orange juice had no such effects. Six healthy men took nifedipine 10 mg with water or grapefruit juice; the bioavailability with grapefruit juice was 134 (108-169)% of that with water.

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