Short reportsExpression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue
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Cited by (260)
Identification of differentially expressed long non-coding RNAs and mRNAs in orbital adipose/connective tissue of thyroid-associated ophthalmopathy
2021, GenomicsCitation Excerpt :Using axial magnetic resonance imaging analysis, it has been determined that for patients with TAO, the orbital fatty tissue volume is more closely related with the degree of exophthalmos than extraocular muscle [6]. Thyroid-stimulating hormone receptor (TSHR), the primary autoantigen in TAO, was first validated by identifying TSHR expression in retro-orbital tissue of cultured orbital fibroblasts from patients with TAO using polymerase chain reaction (PCR) and liquid hybridization [7,8]. Notably, adipogenesis of orbital tissues is positively correlated with the enhanced expression of TSHR in orbital adipose/connective tissues [9].
Thyroid-associated ophthalmopathy: Emergence of teprotumumab as a promising medical therapy
2020, Best Practice and Research: Clinical Endocrinology and MetabolismCitation Excerpt :A shifting focus to the potential involvement of TSHR as an autoantigen shared by the thyroid and orbit was provoked by the successful molecular cloning of the receptor [5]. Feliciello and colleagues reported soon thereafter detecting TSHR mRNA in orbital tissues from both healthy donors and those with TAO [51]. Its expression in orbital fibroblasts was subsequently detected [52], suggesting that these cells might be responsive to TSH.
The evaluation of retrobulbar fat tissue in Graves’ orbitopathy with shear-wave ultrasound elastography
2024, International OphthalmologyImmunological Processes in the Orbit and Indications for Current and Potential Drug Targets
2024, Journal of Clinical MedicineFibrocyte Participation in Thyroid-Associated Ophthalmopathy Suggests New Approaches to Therapy
2023, Ophthalmic Plastic and Reconstructive Surgery