Original articleA cardiotonic steroid bufalin-like factor in human plasma induces leukemia cell differentiation
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2016, FitoterapiaCitation Excerpt :UNBS-1450, a semisynthetic derivative of the natural cardenolide UNBS1244 (isolated from the African plant Calotropis procera), can block cell proliferation in four different human non-small cell lung carcinomas (A549, NCI-H727, A427, and CAL-12T) at nanomolar concentrations, and has also entered phase I clinical trial in Belgium [10–12]. More than that, several studies have revealed the effective dose of cardenolides on inducing apoptosis in human tumor cells with no significant toxicity on normal cells [13–15]. Many of the plants from Apocynaceae family are known to contain cardenolides, mainly distributing in the genera of Nerium, Thevetia, Cerbera, Apocynum and Strophanthus.
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