The metabolic basis of 3-methylindole-induced pneumotoxicity
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2023, BiochimieCitation Excerpt :Although it is logical to investigate the role of skatole in intestinal patho-/physiology due to its possibly high local concentrations, the case reveals another organ where skatole was found to be toxic. This organ is the lungs, and skatole pulmonotoxicity was demonstrated in various species (such as cattle or rodents) but not in boars or pigs [118]. In particular, ruminants are highly susceptible given that a skatole dose of 20–40 mg/kg body weight (BW) is usually fatal within 72 h after intravenous infusion or intraruminal administration, e.g., for goats, cattle, and sheep [119,120].
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Current address: UBC Pulmonary Research Laboratory, St Paul's Hospital, 1081 Burrard Street, Vancouver, B.C. V6Z 1Y6, Canada.