Modulation of lipopolysaccharide-induced tumor necrosis factor-α and nitric oxide production by dopamine receptor agonists and antagonists in mice
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Cited by (45)
Lipopolysaccharide/D-galactosamine-induced acute liver injury could be attenuated by dopamine receptor agonist rotigotine via regulating NF-κB signaling pathway
2021, International ImmunopharmacologyCitation Excerpt :And Zhang’s research showed that DRD2 can control renal inflammation via inducing the levels of p-Akt and p-NFκBp65 and the expression of TNF-α and IL-6 [20]. Studies showed that DA can reduce the secretion of TNF-α and IL-1β in LPS-treated macrophages and microglial cells [21,22]. It has also been shown that the DA receptor agonist pramipexole can inhibit the expression of inflammatory cytokines, such as IL-17, IL-1β and TNF-α in peripheral lymphoid tissues [23].
Targeting of G-protein coupled receptors in sepsis
2020, Pharmacology and TherapeuticsCitation Excerpt :Stimulation of β-adrenoceptors leads to an increase in the intracellular concentration of cAMP in immune cells. Consequently, increase in intracellular cAMP concentration by phosphodiesterase inhibitors and dopamine receptor agonists has been demonstrated to have a similar impact on cytokine secretion from immune cells (Hasko et al., 1996; Hasko, Nemeth, Vizi, Salzman, & Szabo, 1998). Stimulation of β-adrenoceptors also has an impact on the adaptive immune response by inhibiting the release of IFNγ and stimulating the release of IL-10; this inhibits the formation of TH1 cells and promotes differentiation into TH2 cells (Panina-Bordignon et al., 1997).
The role of neutrophils in neuro-immune modulation
2020, Pharmacological ResearchCitation Excerpt :This down-regulation is mediated by sunlight stimulation of β3ARs [79]. Another catecholamine that showed a great anti-inflammatory potential is dopamine [80,81]. There are two families of dopaminergic receptors: D1-type (including D1 and D5 subtypes) and D2-type (D2, D3, and D4 subtypes) [82].
Dopamine alleviated acute liver injury induced by lipopolysaccharide/D-galactosamine in mice
2018, International ImmunopharmacologyCitation Excerpt :These findings suggest that DA might have anti-inflammatory effects in LPS/D-Gal-exposed mice. In agreement with our findings, DA inhibited LPS-induced production of TNF-α and NO in macrophages or glial cells [14, 16], DA also inhibited the elevation of TNF-α in neurodegenerative diseases such as Parkinson's disease [30–33]. Thus, the anti-inflammatory properties of DA might be responsible for, at least partially, its beneficial effects on LPS/D-Gal-induced acute liver injury.
Paracrine Regulation of Renal Function by Dopamine
2013, Seldin and Geibisch's The KidneyParacrine Regulation of Renal Function by Dopamine
2012, Seldin and Giebisch's The Kidney: Physiology and Pathophysiology