Trends in Pharmacological Sciences
Receptor sites for Ca2+ channel antagonists
References (36)
- et al.
Trends Pharmacol. Sci.
(1991) - et al.
J. Mol. Cell. Cardiol.
(1989) FEBS Lett.
(1987)- et al.
J. Biol. Chem.
(1986) J. Biol. Chem.
(1987)- et al.
J. Biol. Chem.
(1987) - et al.
Trends Biochem. Sci.
(1990) - et al.
J. Biol. Chem.
(1990) - et al.
Neuron
(1991) - et al.
J. Biol. Chem.
(1989)
J. Biol. Chem.
Annu. Rev. Pharmacol. Toxicol.
Nature
Pflugers Arch.
Annu. Rev. Pharmacol. Toxicol.
Nature
J. Gen. Physiol.
Cited by (353)
Design, synthesis, and anticancer activity of iridium(III) complex-peptide hybrids that contain hydrophobic acyl groups at the N-terminus of the peptide units
2019, Journal of Inorganic BiochemistryCitation Excerpt :Note that the complexation of 7d with CaM is attributed to its cationic peptide portion, because the Ir complex 8 without the cationic peptide part had a negligible affinity for CaM and the peptide alone 14b binds weakly to CaM. It is described that programed cell death can be classified into apoptosis, necroptosis, paraptosis, autophagic cell death, and so on [26–51]. In our previous study, we reported that cell death induced by 3a (with a peptide at the 5′-position) was not inhibited by a broad caspase inhibitor, Z-VAD-fmk [18], while inhibition was observed in the presence some inhibitors related to Ca2+ homeostasis including 3-chlorophenylhydrazone (CCCP, an uncoupling reagent and an inhibitor of mitochondrial Ca2+ uptake) [44,45], verapamil (an L-type voltage-operated Ca2+ channel blocker) [46–48], quinidine (a Na+ and K+ channel blocker) [49,50] and xestospongin C (a selective inhibitor of the IP3 receptor on the ER which releases Ca2+ into the cytosol) [51,52].
A cell-based assay for the detection of pathogenic anti-voltage-gated calcium channel autoantibodies in immunoglobulin G from patients with type 1 diabetes
2018, Journal of Immunological MethodsCitation Excerpt :Co-incubation of cells with both Bay K8644 and nicardipine reduced the number of DCF-DA positive cells compared to Bay K8644 alone, with a significant reduction in DCF-DA positive cells achieved at 10 nM nicardipine (Fig. 1 B). Previous studies have demonstrated that the serum, or the IgG fraction, from patients with T1D contains a functional Ab that acts as an agonist at the DHP binding site of L-Type VGCCs, and disrupts channel-mediated physiological responses in live tissue or cell-based assays (Catterall and Striessnig, 1992; Jackson et al., 2004; Jackson and Gordon, 2010). Recent reports indicate that these anti-VGCC Abs are capable of mediating over-activity of VGCCs in cultured pancreatic β cell lines, resulting in altered ion exchange and induction of apoptosis (Chang et al., 2004; Bason et al., 2013; Yang et al., 2015).
Use of calcium channel blockers for glaucoma
2011, Progress in Retinal and Eye ResearchOlive Oil Phenols and Nitric Oxide Affect Lymphomonocyte Cytosolic Calcium
2010, Olives and Olive Oil in Health and Disease Prevention