Trends in Pharmacological Sciences
Current awarnessMultiple GABAB receptors
References (25)
- et al.
Brain Res.
(1987) Eur. J. Pharmacol.
(1990)- et al.
Neuron
(1988) - et al.
Eur. J. Pharmacol.
(1988) - et al.
Eur. J. Pharmacol.
(1993) - et al.
Eur. J. Pharmacol.
(1974) - et al.
Neuroscience
(1992) Eur. J. Pharmacol.
(1992)Nature
(1980)- et al.
Nature
(1981)
Pharmacol. Comm.
J. Physiol.
Cited by (210)
Regional Fos-expression induced by γ-hydroxybutyrate (GHB): Comparison with γ-butyrolactone (GBL) and effects of co-administration of the GABA<inf>B</inf> antagonist SCH 50911 and putative GHB antagonist NCS-382
2014, NeuroscienceCitation Excerpt :In three of these regions, the Islands of Calleja, parasubthalamic nucleus and nucleus of the solitary tract, GHB also increased Fos expression. However, when the two drugs were combined, the effects on Fos expression were no different than when the drugs were given alone, suggesting no additive effects The induction of Fos by SCH 50911 may reflect reduction in GABAB receptor-mediated inhibitory tone on receptors located on both GABAergic and non-GABAergic neurons (Bonanno and Raiteri, 1993; Crunelli et al., 2006). Antagonism of GABAB autoreceptors would increase endogenous GABA release, which would mimic some of the effects of GHB-derived GABA (Hechler et al., 1997; Gobaille et al., 1999) and therefore both GHB and SCH 50911 could activate similar brain regions.
Presynaptic mGlu7 receptors control GABA release in mouse hippocampus
2013, NeuropharmacologyCitation Excerpt :The inhibitory effect caused by (−)baclofen was additive to that evoked by 10 nM AMN082 (Fig. 7A). The (−)baclofen-induced inhibition of12 mM K+-evoked release of [3H]GABA was reverted by the GABAB antagonist 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl) phosphinic acid (CGP52432) (Bonanno and Raiteri, 1993), but was insensitive to the mGlu7 antagonist MMPIP (10 nM). Conversely, the AMN082-induced inhibition of 12 mM K+-evoked release of [3H]GABA was prevented by MMPIP (see Fig. 2) but was insensitive to CGP52432 (1 μM).
GABA <inf>B</inf> receptors. Physiological functions and mechanisms of diversity
2010, Advances in PharmacologyCitation Excerpt :As highlighted in the previous section, GABAB receptors are involved in a variety of neuronal functions. During the past 20 years, heterogeneous native GABAB responses suggested the existence of multiple receptor subtypes (Bonanno & Raiteri, 1993b; Raiteri, 2006, 2008). Below, we review some of the pharmacological and functional evidence for differences between (A) pre- and postsynaptic GABAB receptors, (B) presynaptic GABAB auto- and heteroreceptors, and (C) postsynaptic GABAB receptors on different cell types.
Behavioral analyses of GHB: Receptor mechanisms
2009, Pharmacology and TherapeuticsIn vitro modulation of gamma amino butyric acid (GABA) receptor expression by bone marrow stromal cells
2008, Pharmacological Research