Trends in Pharmacological Sciences
ReviewsCloned adenosine A3 receptors: Pharmacological properties, species differences and receptor functions
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Adenosine and its receptors as therapeutic targets: An overview
2013, Saudi Pharmaceutical JournalCitation Excerpt :It has also been shown to stimulate directly phospholipases C and D. A3 receptor activation also results in the influx of calcium and its release from intracellular stores (Jacobson, 1998). The A3 receptor usually exhibits large differences in structure, tissue distribution and its functional and pharmacological properties between species (Linden, 1994). A3 mediated degranulation of mast cells or enhancement of allergen induced mast cell degranulation may be important in animal models of allergic responses.
Selective and potent adenosine A<inf>3</inf> receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold
2013, European Journal of Medicinal ChemistryCitation Excerpt :Among the ARs, A3ARs are the latest cloned and pharmacologically characterized. The A3AR is involved in a variety of important physiological processes, including modulation of cerebral and cardiac ischemic damage [4,5], inflammation [6], modulation of intraocular pressure [7], regulation of normal and tumor cell growth [8,9] and immunosuppression [10]. However, A3-signaling in several processes is still controversial [11,12], being perhaps the most enigmatic among adenosine receptors.
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