Trends in Neurosciences
Volume 13, Issue 7, July 1990, Pages 272-274, C1-C4, 275-276
Journal home page for Trends in Neurosciences

Review
Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

https://doi.org/10.1016/0166-2236(90)90108-MGet rights and content

Abstract

Recent animal experiments suggest that dopamine plays a less crucial role than formerly supposed in the regulation of psychomotor functions. This is illustrated by the finding that even in the almost complete absence of brain dopamine, a pronounced behavioural activation is produced in mice following suppression of glutamatergic neurotransmission. This paper discusses the possibility that a deficient activity within the corticostriatal glutamatergic/aspartergic pathway may be an important pathophysiological component in schizophrenia, and that glutamatergic agonists may be beneficial in the treatment of this disease. In addition, it is suggested that glutamatergic antagonists may be valuable supplements in the treatment of Parkinson's disease.

References (61)

  • J.S. Kim et al.

    Neurosci. Lett.

    (1980)
  • J. Kornhuber et al.

    Life Sci.

    (1986)
  • J.C. Stoof et al.

    Eur. J. Pharmacol.

    (1982)
  • T. Hattori et al.

    Brain Res.

    (1982)
  • Y. Umeda et al.

    Eur. J. Pharmacol.

    (1989)
  • T.F. Freund et al.

    Neuroscience

    (1984)
  • M.W. Warenycia et al.

    Neuropharmacology

    (1987)
  • M.W. Warenycia et al.

    Prog. Neuropsychopharmacol. Biol. Psychiatry

    (1984)
  • M. Johnson et al.

    Eur. J. Pharmacol.

    (1989)
  • A.L. Gundlach et al.

    Brain Res.

    (1986)
  • W.J. Schmidt et al.

    Pharmacol. Biochem. Behav.

    (1989)
  • R.B. Raffa et al.

    Life Sci.

    (1989)
  • R.G. Robertson et al.

    Brain Res.

    (1989)
  • R.L. Albin et al.

    Brain Res.

    (1989)
  • H.T. Nagamoto et al.

    Biol. Psychiatry

    (1989)
  • T. Nishikawa et al.

    Neurosci. Lett.

    (1983)
  • J.F.W. Deakin et al.

    Schizophr. Res.

    (1990)
  • D. Corbett

    Behav. Brain Res.

    (1989)
  • A.R. Crossman et al.

    Neuropharmacology

    (1989)
  • R.L. Albin et al.

    Trends Neurosci.

    (1989)
  • J. Lehmann et al.

    Brain Res.

    (1982)
  • M. Xu et al.

    Brain Res.

    (1989)
  • J.T. Greenamyre et al.

    Neurosci. Lett.

    (1989)
  • A. Carlsson

    Neuropsychopharmacology

    (1988)
  • C.W. Cotman et al.
  • E.H.F. Wong
  • P.K. Sonsalla et al.

    Science

    (1989)
  • A. Hudson et al.

    Br. J. Pharmacol.

    (1989)
  • M. Carlsson et al.

    J. Neural Transm.

    (1989)
  • M. Carlsson et al.

    J. Neural Transm.

    (1989)
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