Research report
A selective role for dopamine in the nucleus accumbens of the rat in random foraging but not delayed spatial win-shift-based foraging

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Abstract

The role of mesoaccumbens dopamine (DA) in radial-arm maze foraging is assessed by infusing low doses of the DA antagonist haloperidol into the nucleus accumbens (N.Acc.). Infusions of haloperidol (0, 125, 250 or 500 ng/0.5 μl) into the N.Acc. of well-trained rats dose-dependently increase the number of re-entries to arms (errors) during the random foraging task, in which 4 arms on an 8-arm maze are baited randomly. However, in a separate group of animals, similar infusions produce no impairment when delivered prior to the test phase of the delayed spatial win-shift task, which require the animal to acquire information during a training phase, and to use that information 30 min later, during a test phase. These results suggest that DA neurotransmission in the N.Acc. is crucial for foraging behavior when there is ambiguity about the location of reward in a spatial environment, but is not needed for efficient foraging behavior when an animal has previous information as to the location of rewarding stimuli. The results are discussed with respect to of the underlying physiological interactions between limbic glutamate and mesoaccumbens DA transmission in the N.Acc.

References (49)

  • K. Muramoto et al.

    Rat amygdaloid neuron responses during auditory discrimination

    Neuroscience

    (1993)
  • P. O'Donnell et al.

    Tonic D2-mediated attenuation of cortical excitation in nucleus accumbens neurons recorded in vitro

    Brain Res.

    (1994)
  • M.G. Packard et al.

    Posttraining injection of the acetylcholine M2 receptor antagonist AF-DX 116 improves memory

    Brain Res.

    (1990)
  • C.M. Pennartz et al.

    The nucleus accumbens as a complex of functionally distinct neuronal ensembles: an integration of behavioural, electrophysiological and anatomical data

    Prog. Neurobiol.

    (1994)
  • T.W. Robbins et al.

    Functions of dopamine in the dorsal and ventral striatum

    Sem. Neurosci.

    (1992)
  • K. Taghzouti et al.

    Alternation behavior, spatial discrimination and reversal disturbances following 6-hydroxydopamine lesions in the nucleus accumbens

    Behav. Neural Biol.

    (1985)
  • N.M. White et al.

    Acquisition of a spatial conditioned place preference is impaired by amygdala lesions and improved by fornix lesions

    Behav. Brain Res.

    (1993)
  • C.R. Yang et al.

    Hippocampal signal transmission to the mesencephalic locomotor regions and its regulation by dopamine D-2 receptors in the nucleus accumbens: an electro physiological and behavioral study

    Neuroscience

    (1987)
  • C.Y.Y. Yim et al.

    Electrophysiological evidence of modulatory interactions between dopamine and cholecystokinin in the nucleus accumbens

    Brain Res.

    (1991)
  • C.D. Blaha et al.

    Frequency-dependent modulation of dopamine release following hippocampal stimulation in vivo

    Soc. Neurosci Abstr.

    (1995)
  • J.S. Brog et al.

    The patterns of afferent innervation of the core and shell in the ‘accumbens’ part of the rat ventral striatum: immunohistochemical detection of retrogradely transported Fluro-Gold

    J. Comp. Neurol.

    (1993)
  • J.F. DeFrance et al.

    Dopamine action in the nucleus accumbens

    J. Neurophysiol.

    (1985)
  • S.B. Dunnett

    Role of prefrontal cortex and striatal output systems in short-term memory deficits associated with aging, basal forebrain lesions, and cholinergic-rich grafts

    Can. J. Psychiatry

    (1990)
  • H.C. Fibiger et al.

    Mesocorticolimbic dopamine systems and reward

    Ann. New York Acad. Sci.

    (1988)
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