Chemoattractant capacity of bombesin, gastrin-releasing peptide and neuromedin C is mediated through PKC activation in murine peritoneal leukocytes
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2017, Pharmacological ReportsCitation Excerpt :NML is found to have a contractile function on the guinea pig ileum. NMC produces a contractile effect on the uterus of guinea pig [82]. NMU-8 causes an increased level of electrogenic ion transport mechanism, by exhibiting a positive mechanism by causing contractions of longitudinal muscles in the porcine jejunal mucosa.
Gastrin-releasing peptide receptor signaling in the integration of stress and memory
2014, Neurobiology of Learning and MemoryCitation Excerpt :GRP acts by binding to the GRP receptor (GRPR, also called BB2), located on cell membranes. Over the past three decades accumulating evidence has suggested that the GRP/GRPR system influences a broad spectrum of physiological processes including thermal regulation, glicemia, feeding, gastrin and somatostatin release, gastric acid secretion, pancreatic secretion, gastrointestinal motility, lung development, pain perception, itch responses, memory formation and expression, stress responses, cell proliferation, and chemoattraction in the immune system (Brown, Rivier, & Vale, 1977a, 1977b; Czepielewski et al., 2012; Del Rio & De la Fuente, 1994; Gibbs & Smith, 1988; Gibbs et al., 1979; Gonzalez, Moody, Igarashi, Ito, & Jensen, 2008; Jensen, Battey, Spindel, & Benya, 2008; Niebergall-Roth & Singer, 2001; Ohki-Hamazaki, Iwabuchi, & Maekawa, 2005; Pert, Moody, Pert, Dewald, & Rivier, 1980; Roesler & Schwartsmann, 2012; Ruff, Schiffmann, Terranova, & Pert, 1985; Schubert, Hightower, Coy, & Makhlouf, 1991; Sun & Chen, 2007). In the central nervous system (CNS), GRP may act as a transmitter to activate GRPRs located on postsynaptic neuronal membranes, regulating several aspects of brain function (Moody & Merali, 2004; Roesler & Schwartsmann, 2012; Shumyatsky et al., 2002).
The role of bombesin and bombesin-related peptides in the short-term control of food intake
2013, Progress in Molecular Biology and Translational ScienceCitation Excerpt :In addition, the BB2 receptor mediates stimulation of pancreatic exocrine secretion180,181 and the release of insulin182 and other hormones, including CCK, PYY, and glucagon.60,183–185 This receptor also participates in immunological responses such as attracting peritoneal macrophages, monocytes, and lymphocytes.98,99,102 The BB2 receptor has also been shown to participate in lung development..186
Direct antimicrobial activities of PR-bombesin
2006, Life Sciences