Control of the biodegradation rate of poly (dl-lactide) microparticles intended as chemoembolization materials
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Process conditions for preparing well-defined nano- and microparticles as delivery systems of alkyl gallates
2019, ParticuologyCitation Excerpt :Taking into account the size of the microparticles and assuming that, similarly to nanoparticles, the release was limited by diffusion within the solid core, this result appeared fully consistent. It has been shown that pH can significantly influence the kinetics of drug release from a PLA matrix as a result of: variation of drug solubility and swelling and hydrolytic degradation of the PLA matrix (Grandfils, Flandroy, & Jerome, 1996; Proikakis, Mamouzelos, Tarantili, & Andreopoulos, 2006; Proikakis, Tarantili, & Andreopoulos, 2006). As a consequence, AG release from microparticles was carried out in a Tris/HCl buffer, pH 8.5.
Design of deformable chitosan microspheres loaded with superparamagnetic iron oxide nanoparticles for embolotherapy detectable by magnetic resonance imaging
2012, Carbohydrate PolymersCitation Excerpt :In addition, deformability and softness were essential for easy delivery through the narrow catheter tip (Beaujeux et al., 1996). Microspheres used for arterial embolization have been made from numerous biomaterials, such as polyvinyl alcohol, trisacryl gelatin, polyhydroxybutyrate (PHB), and polylactide (Bendszus et al., 2000; Grandfils, Flandroy, & Jerome, 1996; Kassab, Piskin, Bilgic, Denkbas, & Xu, 1999; Shomura et al., 2010). Thus, embolic materials currently used in clinical practice are fabricated with synthetic polymers or chemically modified natural polymers.
Paclitaxel-loaded poly(L-lactic acid) microspheres 3: Blending low and high molecular weight polymers to control morphology and drug release
2004, International Journal of PharmaceuticsMethotrexate Loaded Poly(L-Lactic Acid) Microspheres for Intra-Articular Delivery of Methotrexate to the Joint
2004, Journal of Pharmaceutical SciencesCitation Excerpt :During the first day of the degradation study, there was an apparent increase in the molecular weight of the polymer (Fig. 5A), which was likely due to the rapid leaching of a very low molecular weight fraction of the polymer matrix, resulting in an increase in the average molecular weight of the polymer. Liggins and Burt30 reported that approximately one-third of 1 kg/mole PLLA was water soluble and GPC analysis of the water soluble fraction of low molecular weight PDLLA showed that the highest molecular weight that dissolved in water was approximately 650 g/mol.31 It has also been shown that the average molecular weight of PLLA films increased from 22000 to 30000 g/mole during the first week of degradation in a mineral medium at 37°C due to the extraction of low molecular weight products that became soluble in the mineral medium.32
Hydrolytic degradation of poly(lactide-co-glycolide) films: Effect of oligomers on degradation rate and crystallinity
2003, International Journal of Pharmaceutics