Trends in Genetics
Volume 7, Issue 10, October 1991, Pages 329-334
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HOX gene activation by retinoic acid

https://doi.org/10.1016/0168-9525(91)90423-NGet rights and content

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  • Cited by (200)

    • Opposing roles for the lncRNA haunt and its genomic locus in regulating HOXA gene activation during embryonic stem cell differentiation

      2015, Cell Stem Cell
      Citation Excerpt :

      Under this condition, Haunt transcripts were rapidly downregulated and HOXA genes remained silenced (Table S1), implying the need for a relevant biological context in which to assess Haunt function. RA is a well-characterized morphogen that regulates the spatial and temporal activation of HOX genes in vivo and in vitro (Boncinelli et al., 1991). Interestingly, the addition of RA not only activated HOXA genes but also enhanced the expression of Haunt (Figure 2A).

    • Retinoic acid receptors: From molecular mechanisms to cancer therapy

      2015, Molecular Aspects of Medicine
      Citation Excerpt :

      Thus, Ajuba also functions as a unique co-repressor for RAR/RXR (Hou et al., 2010). The HOX gene family is a large set of RA-regulated genes (Table 6) with a pivotal role in development and cell differentiation (Boncinelli et al., 1991; Langston and Gudas, 1994; Marshall et al., 1996). RAR binds to RAREs on HOX; subsequently the RA-induced transcriptional activation takes place (Dupé et al., 1997; Marshall et al., 1994; Thompson, 1997).

    • A high-throughput method for monitoring changes in homeobox gene expression

      2007, Biochemical and Biophysical Research Communications
      Citation Excerpt :

      The expression of some of these genes, Hoxa1/Hox1.6, Hoxa4/Hox1.4, Hoxa5/Hox1.3[15], Hoxb9/Hox2.5[16], Hoxb2/Hox2.8, Hoxb8/Hox2.4[17], Hoxd4[18], HoxB locus genes [19], and Gbx2/Stra7[20], has been shown previously by Northern analysis to be upregulated by RA in P19 cells cultured in monolayer [15–17,20] or as EBs during nerve cell differentiation [18,19]. Major RA-induced changes in HOX gene expression also have been observed in human EC cells [21]. To determine the effectiveness of this method in detecting changes in homeobox gene expression, P19 cells were allowed to form EBs in the absence or presence of 1 μM RA for 48 and 96 h under serum-free culture conditions.

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