Trends in Genetics
ReviewHOX gene activation by retinoic acid
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Cited by (200)
Opposing roles for the lncRNA haunt and its genomic locus in regulating HOXA gene activation during embryonic stem cell differentiation
2015, Cell Stem CellCitation Excerpt :Under this condition, Haunt transcripts were rapidly downregulated and HOXA genes remained silenced (Table S1), implying the need for a relevant biological context in which to assess Haunt function. RA is a well-characterized morphogen that regulates the spatial and temporal activation of HOX genes in vivo and in vitro (Boncinelli et al., 1991). Interestingly, the addition of RA not only activated HOXA genes but also enhanced the expression of Haunt (Figure 2A).
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2015, Molecular Aspects of MedicineCitation Excerpt :Thus, Ajuba also functions as a unique co-repressor for RAR/RXR (Hou et al., 2010). The HOX gene family is a large set of RA-regulated genes (Table 6) with a pivotal role in development and cell differentiation (Boncinelli et al., 1991; Langston and Gudas, 1994; Marshall et al., 1996). RAR binds to RAREs on HOX; subsequently the RA-induced transcriptional activation takes place (Dupé et al., 1997; Marshall et al., 1994; Thompson, 1997).
Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid
2011, Journal of Biological ChemistryA high-throughput method for monitoring changes in homeobox gene expression
2007, Biochemical and Biophysical Research CommunicationsCitation Excerpt :The expression of some of these genes, Hoxa1/Hox1.6, Hoxa4/Hox1.4, Hoxa5/Hox1.3[15], Hoxb9/Hox2.5[16], Hoxb2/Hox2.8, Hoxb8/Hox2.4[17], Hoxd4[18], HoxB locus genes [19], and Gbx2/Stra7[20], has been shown previously by Northern analysis to be upregulated by RA in P19 cells cultured in monolayer [15–17,20] or as EBs during nerve cell differentiation [18,19]. Major RA-induced changes in HOX gene expression also have been observed in human EC cells [21]. To determine the effectiveness of this method in detecting changes in homeobox gene expression, P19 cells were allowed to form EBs in the absence or presence of 1 μM RA for 48 and 96 h under serum-free culture conditions.
Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis
2024, Scientific ReportsEarly Neuronal Differentiation/patterning of the Human Pallium, Modeling by in Vitro Systems, and Disruption in Developmental Disorders
2023, Neocortical Neurogenesis in Development and Evolution