Effect of α-MSH 11–13 (lysine-proline-valine) on fever in the rabbit
References (22)
- et al.
Comparison of the effects of central administration of serine and glycine on body temperature of the rabbit
Brain Res Bull
(1980) - et al.
Central administration of serine causes hypothermia and inhibits fever in rabbits
Brain Res Bull
(1980) - et al.
Effects of central administration of alanine on body temperature of the rabbit: comparisons with the effects of serine, glycine and taurine
Brain Res Bull
(1981) - et al.
Hypothermic and antipyretic effects of centrally administered ACTH (1–24) and α-melanotropin
Peptides
(1981) - et al.
α-MSH injected into the septal region reduces fever in rabbits
Peptides
(1983) - et al.
Central administration of peptides alters thermoregulation in the rabbit
Peptides
(1980) - et al.
Polypeptide influences on attention, memory and anxiety in man
Pharmacol Biochem Behav
(1974) - et al.
The effect of fever on central α-MSH concentrations in the rabbit
Peptides
(1981) - et al.
Enhancement of attention in man with ACTH/α-MSH 4–10
Physiol Behav
(1975) Effects of peptide hormones on behavior
Structure and chemistry of the peptide hormones of the intermediate lobe
Cited by (63)
Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes
2020, European Journal of PharmacologyCitation Excerpt :With respect to IL-6 and IL-8, KPV demonstrated a reduced anti-inflammatory effect in this study even though it has previously been shown to have similar effects to α-MSH on elevated intracellular calcium fluxes (Brzoska et al., 2008). In a study in rabbits central effects of KPV were more pronounced than peripheral administration with effects less than α-MSH (Richards and Lipton, 1984) suggesting that full activity requires other regions of the hormone (HFRW). However, for IL-1β, KPV appeared to cause a similar degree of inhibition as α-MSH both prophylactically and therapeutically and could be due to the fact that the L form of K(D)PT is similar to IL-1β193-195 and is well tolerated in ulcerative colitis (Kucharzik et al., 2017).
Brain effects of melanocortins
2009, Pharmacological ResearchTargeting melanocortin receptors as potential novel therapeutics
2006, Pharmacology and TherapeuticsInhibitory effects of the peptide (CKPV)<inf>2</inf> on endotoxin-induced host reactions
2006, Journal of Surgical ResearchThe melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage
2006, European Journal of Pharmacology
- 1
Present address: University of Texas Health Science Center at San Antonio, TX.