ArticlePancreatic polypeptide infusions reduce food intake in Prader-Willi syndrome
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Pancreatic polypeptide revisited: Potential therapeutic effects in obesity-diabetes
2023, PeptidesCitation Excerpt :Accordingly, peripheral administration of PP results in reduced energy intake in rodents [61] and healthy humans [7]. Indeed, a blunted PP secretion was first observed in obese hyperphagic Prader-Willi patients [108] with exogenous PP application able to reduce food intake in these patients [9]. Furthermore, in people with bulimia nervosa, reduced circulating levels of PP in response to food ingestion are observed [69], whilst in anorexia nervosa plasma PP concentrations are elevated [25], which likely contributes to the pathophysiology of these disorders in humans.
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