Mercury-metallothionein and the renal accumulation and handling of mercury
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Mechanisms Involved in the Renal Handling and Toxicity of Mercury
2018, Comprehensive Toxicology: Third EditionXenobiotic transporters and kidney injury
2017, Advanced Drug Delivery ReviewsCitation Excerpt :This strong affinity also contributes to the mechanism of toxicity where binding of mercuric ions to critical proteins can initiate cell injury pathways. Binding of mercuric ions to thiol-rich proteins, such as metallothionein, also increases intracellular retention [205–207]. The Cys-conjugated species of both inorganic and organic mercury seem to be the primary form found in proximal tubular cells.
Mercury exposure and omega-3 fatty acid intake in relation to renal function in the US population
2014, International Journal of Hygiene and Environmental HealthCitation Excerpt :Further investigation of this possibility is warranted. Inorganic Hg can concentrate in the kidney via metallothionein binding and transport, with some of this renal burden excreted as inorganic Hg in the urine (Zalups et al., 1993). The role of the kidney in Hg storage and excretion lead to the potential for exposure and toxicity within this organ.
Renal Handling and Toxicity of Mercury
2010, Comprehensive Toxicology, Second EditionMolecular handling of cadmium in transporting epithelia
2003, Toxicology and Applied Pharmacology