Effect of different renal glutathione levels on renal mercury disposition and excretion in the rat
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Mechanisms Involved in the Renal Handling and Toxicity of Mercury
2018, Comprehensive Toxicology: Third EditionN-acetyl cysteine and selenium protects mercuric chloride-induced oxidative stress and antioxidant defense system in liver and kidney of rats: A histopathological approach
2014, Journal of Trace Elements in Medicine and BiologyCitation Excerpt :Animals of groups 2–5 were administered HgCl2 (12 μ mol kg−1, i.p., once only) [12] and group 2 served as experimental control. Groups 3, 4 and 5 were treated with N-acetyl cysteine (NAC) (0.6 mg kg−1 i.p.) [13], selenium (Se) (0.5 mg kg−1 p.o.) [14] and combined treatment with NAC + Se, respectively, for three days after 24 h of mercuric chloride administration. Animals of all groups were killed after 24 h of the last treatment.
Therapeutic potential of N-acetyl cysteine with antioxidants (Zn and Se) supplementation against dimethylmercury toxicity in male albino rats
2012, Experimental and Toxicologic PathologyCitation Excerpt :Dimethylmercury was suspended in olive oil at a concentration of 5 ml/kg and administered by single oral gavage at a dose of 10 mg/kg body weight (RTECS, 1985–1986). The selection of the doses of therapeutic agents as N-acetyl cysteine (NAC) (2 mM/kg, i.p.) intraperitoneally by Giradi and Elias (1993), zinc (2 mM/kg, p.o.) by Fukino et al. (1984) and selenium (0.5 mg/kg, p.o.) according to Johri et al. (2002) as well as our previous studies (Joshi et al., 2010). Equal amount of olive oil was given as vehicle to control animals.
Molecular characterization and functions of zebrafish ABCC2 in cellular efflux of heavy metals
2011, Comparative Biochemistry and Physiology - C Toxicology and PharmacologyCitation Excerpt :As shown in Fig. 8A and B, a strong linear correlation between the luciferase activity and cadmium concentration was obtained (R2 = 0.974). Moreover, it has been shown that elevated intracellular GSH content can facilitate the excretion of heavy metals (Ballatori and Clarkson, 1985; Girardi and Elias, 1993). Thus, we next investigated the effect of GSH preloading on the excretion of heavy metals in ZF4 cells.
Renal Handling and Toxicity of Mercury
2010, Comprehensive Toxicology, Second EditionCytoprotective Systems within the Kidney
2010, Comprehensive Toxicology, Second Edition