Elsevier

Biochimie

Volume 76, Issue 8, 1994, Pages 761-769
Biochimie

Regulation of heme-regulated eIF-2α kinase and its expression in erythroid cells

https://doi.org/10.1016/0300-9084(94)90080-9Get rights and content

Abstract

In this article we focus first on the molecular mechanisms controlling the activity of the heme-regulated translational inhibitor, HRI, in erythoid cells. Then we discuss the tissue-specific expression of HRI. The experimental evidence obtained to date indicates that the major physiological role of HRI is in adjusting the synthesis of globin to the availability of heme.

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