Rapid paperACTH induces up-regulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines
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2018, Toxicology in VitroCitation Excerpt :However, H295R cells express low levels of the ACTH receptor. This leads to low response or even a complete resistance to ACTH stimulation (Mountjoy et al., 1994). Therefore, stimulation of the cAMP-pathway in these cells can be performed using a cAMP-elevating agent such as forskolin (Rainey et al., 1993).
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2013, Molecular and Cellular EndocrinologyCitation Excerpt :Furthermore, our data are in contrast to previous reports in the mouse where no circadian variation of SF-1 or DAX1 has been observed (Oster et al., 2006a; Son et al., 2008), which may be due to species variation. Although the MC2R gene is induced by ACTH (Mountjoy et al., 1994), our data show that the circadian rhythm of MC2R mRNA is characterized by higher levels of expression in the morning, when ACTH is minimal, and this is in agreement with previous studies in rodents (Kalsbeek et al., 2012; Oster et al., 2006a). Due to unavailability of a suitable antibody, we could not investigate whether this reversed circadian rhythm in MC2R mRNA is also found in the protein.
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2011, Molecular Genetics and MetabolismCitation Excerpt :Expression of this receptor has also been restricted to a limited number of cell types, indicating that an extremely effective mechanism exists to repress expression of this receptor in other tissues [42]. Regulation of the ACTH receptor after stimulation with the ACTH ligand occurs through a signaling cascade ultimately activating protein kinase A [42,43]. Additionally, human MC2R accessory protein (MRAP) plays an important role in localizing the ACTH receptor to the plasma membrane [44].
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