Behavioral activation induced in the rat by substance P infusion into ventral tegmental area: Implication of dopaminergic A10 neurones☆
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Cited by (89)
Activation of Preoptic Tachykinin 1 Neurons Promotes Wakefulness over Sleep and Volatile Anesthetic-Induced Unconsciousness
2021, Current BiologyCitation Excerpt :Injections of substance P into the brainstem of lampreys, rodents, and cats induce bouts of locomotor activity, suggesting an evolutionarily conserved role for tachykinins in modulating locomotion.48–51 Additionally, substance P and neurokinin A, another product of the Tac1 gene, produce a dopamine-mediated increase in locomotor activity in an open field when injected into the VTA of rats.52–54 To our knowledge, the endogenous source of tachykinins in these regions has yet to be identified.
Substance P and the Neurokinin-1 Receptor: The New CRF
2017, International Review of NeurobiologyCitation Excerpt :Also, NK1R antagonists prevent the increased striatal DA that is induced by cocaine administration (Kraft, Noailles, & Angulo, 2001; Noailles & Angulo, 2002). Intracranial SP infusion induces increased locomotion, and this is reversed by DA antagonism or 6-OH-DA lesions of dopamine cells (Kelley, Stinus, & Iversen, 1979). For NE function specifically, SP infusion into the locus coeruleus increases neuronal firing in this noradrenergic brainstem nucleus (Cheeseman, Pinnock, & Henderson, 1983; Guyenet & Aghajanian, 1977).
Role of substance P in the cardiovascular system
2016, NeuropeptidesCitation Excerpt :Application of NK1 receptor agonist into the VTA increases the firing rate of A10 dopamine cells (Overton et al., 1992), which are engaged in diurnal blood pressure and heart rate regulation (Sakata et al., 2002). Dopamine involvement in this process has been proven by an application of DA receptor antagonist, which blocks the effect of SP or NK1 agonists on neurones in VTA (Elliott et al., 1992, Kelley et al., 1979). Further study demonstrated that dopaminergic receptors responsible for the effect are of type D1 (Deschamps and Couture, 2005).
Stress-Related Neuropeptides and Addictive Behaviors: Beyond the Usual Suspects
2012, NeuronCitation Excerpt :The majority of these neurons feed back onto the substantia nigra (SN), a region that contains dopaminergic cell bodies and expresses NK1Rs (Futami et al., 1998; Le Moine and Bloch, 1995; Whitty et al., 1995). Infusion of SP or SP analogs into the SN or VTA stimulates the firing rate of these neurons and subsequent DA release in their terminal fields (Barnes et al., 1990; West and Michael, 1991), increases locomotor activity (Barnes et al., 1990; Eison et al., 1982; Elliott et al., 1992; Kelley et al., 1979; Placenza et al., 2004), and induces CPP (Boix et al., 1995; Nikolaus et al., 1999). The relative contribution of NK receptor subtypes to the effects of SP in the VTA and SN remains unclear, as the NK3R may also play a role.
Effects of central neurokinin-1 receptor antagonism on cocaine- and opiate-induced locomotor activity and self-administration behaviour in rats
2006, Pharmacology Biochemistry and Behavior
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This work was presented in part at the II European Neuroscience Meeting, Florence, Sept. 4–9, 1978.