Elsevier

Neuroscience Letters

Volume 85, Issue 1, 15 February 1988, Pages 163-167
Neuroscience Letters

Galanin selectively modulates 5-hydroxytryptamine 1A receptors in the rat ventral limbic cortex

https://doi.org/10.1016/0304-3940(88)90448-XGet rights and content

Abstract

The effects of galanin (10 nM) in vitro were analyzed on the binding characteristics of 5-hydroxytryptamine (5-HT) receptor subtypes in the ventral limbic cortex of the rat. It was found that galanin markedly decreased the Kd value of 5-HT1A binding, while there were no effects on the binding characteristics of the 5-HT1B or 5-HT2 radioligands. These results indicate the existence of a selective intramembrane interaction between galanin receptors and 5-HT1A receptors in the rat ventral limbic cortex.

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