Autoregulation of histamine release in brain by presynaptic H3-receptors
Reference (56)
- et al.
Decrease in histamine content and decar☐ylase activities in an isolated area of the cerebral cortex of the cat
Brain Res.
(1975) - et al.
Dual localization of histamine in an ascending neuronal pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic area
Brain Res.
(1976) - et al.
Effects of kainic acid on histaminergic systems in guinea-pig hippocampus
Brain Res.
(1978) Histamine hyperpolarizes hippocampal neurones in vitro
Neurosci. Lett.
(1981)- et al.
Central actions of histamine: microelectrophoretic studies
Brain Res.
(1977) - et al.
Hypersensitivity to histamine in the guinea-pig brain: microiontophoretic and biochemical studies
Brain Res.
(1978) - et al.
Protein measurements with the Folin phenol reagent
J. biol. Chem.
(1951) - et al.
The measurement of glutamate decar☐ylase activity in brain tissues by a simple microradiometric method
Analyt. Biochem.
(1975) - et al.
Release of3H-histamine from rat brain slices by potassium depolarization, electrical stimulation, and veratrine: evidence for uptake and release of histamine by neurons
Neurochem. Int.
(1983) - et al.
Gaba, benzodiazepine and histamine H1-receptors in the guinea-pig cerebellum: effects of kainic acid injections studied by autoradiographic methods
Brain Res.
(1981)
Histamine and the hypothalamus
Neuroscience
Comparison between electrically evoked and potassiuminduced3H-noradrenaline release from rat neocortex slices: role of calcium ions and transmitter pools
Neurochem. Int.
Histamine receptors in the brain and their possible functions
Catabolism of3H-histamine in the rat brain after intracisternal administration
Eur. J. Pharmac.
Electrically induced release of radiolabeled histamine from rat hippocampal slices: opposing roles for H1- and H2-receptors
Life Sci.
Potassium induced release of tritiated histamine from rat brain tissue slices
Eur. J. Pharmac.
A new radioenzymatic assay for histamine using purifiedhistamine-N-methyltransferase
Life Sci.
Synthesis and release of histamine studied on slices from rat hypothalamus
Eur. J. Pharmac.
Atlas Stéréotaxique du Diencéphale du Rat Blanc
Autoinhibition of brain histamine release mediated by a novel class (H3) of histamine receptor
Nature
Histamine synthesizing afferents to the hippocampal region
J. Neurochem.
H1 and H2-receptors in the histamine induced accumulation of cyclic AMP in guinea-pig brain slices
Nature
Electrically-evoked release of [3H]histamine from the guinea-pig hypothalamus
Br. J. Pharmac.
Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
Biochem. Pharmac.
Histaminergic pathway in rat brain evidenced by lesions of the medial forebrain bundle
Science, N.Y.
Methods in brain histamine research
Histamine receptors in brain
Histamine and the central nervous system: analysis of histamine actions by intra and extracellular recording in hippocampal slices of the rat
Agents Actions
Cited by (237)
OLHA (N<sup>α</sup>-oleoylhistamine) modulates activity of mouse brain histaminergic neurons
2022, NeuropharmacologyPharmaceutical significance of azepane based motifs for drug discovery: A critical review
2019, European Journal of Medicinal ChemistryHistamine H<inf>3</inf> Receptors Decrease Dopamine Release in the Ventral Striatum by Reducing the Activity of Striatal Cholinergic Interneurons
2018, NeuroscienceCitation Excerpt :These results denote a concerted interplay between dopamine and histamine, leading to complex physiological and pathophysiological ramifications. Elsewhere in the brain histamine H3 receptors have a well described role as pre-synaptic autoreceptors and heteroreceptors, modulating release of not only histamine (Arrang et al., 1985), but also glutamate (Brown and Haas, 1999), GABA (Yamamoto et al., 1997), serotonin (Threlfell et al., 2004) and acetylcholine (Clapham and Kilpatrick, 1992), among others. However, to date, studies that investigated the effects of histamine H3 receptors on dopamine release have generated conflicting data, indicating either no modulation (Fox et al., 2005; Giannoni et al., 2010; Aquino-Miranda et al., 2015), or decreased dopamine release upon activation of H3 receptors (Schlicker et al., 1993).
Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases
2016, Behavioural Brain ResearchCherry-picked ligands at histamine receptor subtypes
2016, NeuropharmacologyCitation Excerpt :The methylated analog 3H-Nα-methylhistamine (NAMH, 30) (Arrang et al., 1987) is not selective for H3R (vs H1R, H2R), but has found a wide use in radioligand competition binding assays due to its high affinity at rat H3Rs (Arrang et al., 1983; Hill et al., 1997) and ready availability in tritiated form. R-(α)-methylhistamine (28) is highly potent (Arrang et al., 1985a, 1985b; Hill et al., 1997) and is also used as an in vitro agonist tool (Fig. 5). Also, R-(α)-methylhistamine does have significant H4R activity (Liu et al., 2001; Morse et al., 2001; Panula et al., 2015).