Angiotensin ii-(3–8)-hexapeptide affects motor activity, performance of passive avoidance and a conditioned avoidance response in rats

doi:10.1016/0306-4522(88)90182-0

Neuroscience

Volume 27, Issue 3, December 1988, Pages 777-783

https://doi.org/10.1016/0306-4522(88)90182-0 Get rights and content

Abstract

Angiotensin II-(3–8)-hexapeptide, at the dose of 1 nmol given intracerebroventricularly, only slightly less than angiotensin II (the same dose and route) stimulated exploratory locomotor behaviour in an open field and electromagnetic motimeter. Both peptides considerably enhanced stereotyped behaviour produced by apomorphine and amphetamine. Angiotensin II-(3–8)-hexapeptide improved recall in a passive avoidance situation as well as angiotensin II. The 3–8 C-terminus of angiotensin II enhanced acquisition of active avoidance nearly as effectively as the complete peptide.

The results indicate that the effectiveness of equimolar doses of angiotensin II-(3–8)-hexapeptide and angiotensin II in improving processes related to learning and memory in rats is almost identical and thus must be independent of specific angiotensin receptors in brain to which the hexapeptide binds with about 1000 times lower affinity than angiotensin II.

The stimulation of stereotypy, a dopamine-controlled behaviour, by the peptides points to the possibility of dopaminergic mediation of their psychotropic effects.

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Citation Excerpt :
Similarly, Kerr et al. (2005) found that rats which had received i.h. injections of Ang IV were no different from vehicle controls, while Ang II produced a dose-dependent amnesic effect on the passive avoidance task. In contrast to these findings, two studies from the same group (Braszko et al., 1988; Braszko et al., 2006) found that i.c.v. administration of either Ang IV or Ang II in rats significantly improved recall relative to controls, increasing re-entry latencies on the passive avoidance task. The increase was approximately seven-fold in the first study.
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Of 450 articles identified, 32 met inclusion criteria. Seven of 11 studies of normal animals found Ang IV had beneficial effects on tests of passive or conditioned avoidance and object recognition. In models of cognitive deficit, eight of nine studies found Ang IV and its analogs (Nle¹-Ang IV, dihexa, LVV-hemorphin-7) improved performance on spatial working memory and passive avoidance tasks. Two of three studies examining Ang-(1–7) found it benefited memory. Mas receptor removal was associated with reduced fear memory in one study.
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Angiotensin ii-(3–8)-hexapeptide affects motor activity, performance of passive avoidance and a conditioned avoidance response in rats

Abstract

Brain Res.

Brain Res. Rev.

Peptides

Behav. Brain Res.

Life Sci.

Brain Res.

Neurosci. Lett.

Eur. J. Pharmac.

Retention of a passive avoidance response as a function of the intensity and duration of electric shock

Psychon. Sci.

Effect of angiotensin II and vasopressin on acquisition and extinction of conditioned avoidance in rats

Psychopharmacology

Effect of angiotensin II on some behavioral and neurochemical measures of the central serotonin system

Biomed. biochim. Acta

Angiotensin II [AII (3–8)] fragment improves learning and memory in rats

Neuroscience

Approaches to establishing angiotensin II as a neurotransmitter