Stress-induced regulation of the renal peripheral benzodiazepine receptor: Possible role of the renin-angiotensin system

doi:10.1016/0306-4530(94)90058-2

Psychoneuroendocrinology

Volume 19, Issue 1, 1994, Pages 43-54

https://doi.org/10.1016/0306-4530(94)90058-2 Get rights and content

Abstract

The etiology of the decrease in renal peripheral benzodiazepine receptor (PBR) binding caused by stress was studied in rats. Prior investigations suggest that the response of the renal PBR to stress occurs independently of the hypothalamo-pituitary-adrenal (HPA) axis and sympathetic nervous system. The present experiments tested the hypothesis that the renin-angiotensin system is involved in regulating the PBR. Eighty min of brief, intermittent tailshocks caused increases in plasma renin activity and decreases in renal PBR binding. The stress-induced decrease in renal PBR binding was reversed by pretreatment with captopril. Acute administration of angiotensin II (ANG II) alone caused reductions in PBR binding in kidney, heart, and cerebral cortex. These data suggest that ANG II may be an endogenous factor responsible for regulating the PBR in several tissues during stress.

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¹: Current Address: Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, NIMH, Bethesda, MD 20892.

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Stress-induced regulation of the renal peripheral benzodiazepine receptor: Possible role of the renin-angiotensin system

Abstract

Neuropharmacol

Trends Pharm Sci

Biochem Pharmacol

Kidney Internatl

Eur J Pharm

Life Sci

Brain Res Bull

Pharmacol Biochem Behav

Pharmacol Biochem Behav

Pharmacol Biochem Behav

Eur J Pharmacol

Neuropharmacol

Eur J Pharmacol

Brain Res

Pharmacol Biochem Behav

Life Sci

J Biol Chem

Eur J Pharmacol

Eur J Pharmacol

Neuropharmacol

J Biol Chem

Pharmacol Biochem Behav

J Biol Chem

Neuropharmacol

An inducible functional peripheral benzodiazepine receptor in mitochondria of steroidogenic granulosa cells

Endocrinol

Molecular characterization and mitochondrial density of a recognition site for peripheral-type benzodiazepine ligands

Mol Pharmacol

Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells

Am J Physiol

Aldosterone-reversible decrease in the density of renal peripheral benzodiazepine receptors in the rat after adrenalectomy

J Pharmacol Exp Ther