NeuropeptidesImmune cytokines and regulation of body temperature, food intake and cellular immunity
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Cited by (92)
Interferon modulates central nervous system function
2012, Brain ResearchCitation Excerpt :These observations suggest that endogenously IFNs in the brain are involved in feeding regulation as a neurotransmitters or as a neuroregulators Although cytokines such as IFNs suppress food intake independently to fever, it is possible that the increase in temperature caused by IFNs treatment result with inhibition of feeding, and the fever modulates the activity of glucose-responsive neurons in the VMH and LH (Hori et al., 1991). Since IFN-α produces also sleep and sleep prevents eating, less eating results in weight loss.
Menopausal transition: A possible risk factor for brain pathologic events
2009, Neurobiology of AgingCitation Excerpt :Recently, we have shown that CD36 is also expressed by peripheral leukocytes and that its expression by these cells is lower in AD patients than in age-matched controls (Giunta et al., 2006). Peripheral leukocytes express virtually all hormones and hormone receptors, which are under the same regulatory mechanisms that control their expression in the brain (Hori et al., 1991; Kim and de Vellis, 2005). Importantly, the prevailing view about origin of microglia is that it derives from peripheral leukocytes, particularly, monocytes which, during embryonic development, enter the brain from the bloodstream and then differentiate into brain resident microglia, displaying several cell surface antigens described in monocytes (Kim and de Vellis, 2005).
Physiology of temperature regulation: Comparative aspects
2007, Comparative Biochemistry and Physiology - A Molecular and Integrative PhysiologyThe leukocyte expression of CD36 is low in patients with Alzheimer's disease and mild cognitive impairment
2007, Neurobiology of AgingCitation Excerpt :It is also expressed on microglia in normal and AD brain and binds in vitro to β-amyloid (βA) fibrils [3,6,12], thus, allegedly, playing a key role in the proinflammatory events associated with AD [4,14]. Peripheral leukocytes express many molecules and multiple receptors, which undergo the same regulatory mechanisms as those operative in the brain [11]. Thus, these, easily obtainable cells, may be used as a tool to investigate changes occurring in inaccessible brain areas.