Elsevier

Toxicology Letters

Volume 40, Issue 1, January 1988, Pages 71-76
Toxicology Letters

Probenecid-induced protection against acute hexachloro-1, 3-butadiene and methyl mercury toxicity to the mouse kidney

https://doi.org/10.1016/0378-4274(88)90184-1Get rights and content

Abstract

Male Swiss OF1 mice received a single oral dose of either 80 mg/kg hexachloro-1,3-butadiene (HCBD) or 40 mg/kg methyl mercury (MeHg). Examination of cryostat kidney sections stained for alkaline phosphatase (APP) revealed damage to about 50% of the proximal tubules after 8 h. Treatment with the organic anion transport inhibitor probenecid (i.p., 3 × 0.75 mmol/kg) did not have any renal effect in normal mice but reduced the number of damaged tubules by 80 and 90% in mice treated with HCBD and MeHg respectively. The results support the conclusion that the toxicity of HCBD and MeHg to the mouse kidney is related to a probenecid-sensitive transport process. It cannot be stated from the present investigation whether the inhibition nephrotoxicity data are related to classic organic anion secretion by the kidney.

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