Regular article
Anaphylactic shock-induced conditioned taste aversion: II. Correlation between taste aversion and indicators of anaphylactic shock

https://doi.org/10.1016/0889-1591(88)90003-7Get rights and content

Abstract

Previous studies (V. J. Djurić, B. M. Marković, M. Lazarević, & B. D. Janković, 1987, in B. D. Janković, B. M. Marković, & N. H. Spector (Eds.), Neuroimmune interactions, pp. 561–568, New York: New York Acad. Sci.; B. M. Marković, V. J. Djurić, M. Lazarević, & B. D. Janković, 1988, Brain Behav. Immun. 2, 11–23) have shown that rats learn to associate the taste of saccharin with the induction of anaphylactic shock, thus exhibiting conditioned taste aversion (CTA) toward an otherwise preferred saccharin solution. The present experiment investigates the effect of unconditioned stimulus intensity (the amount of antigen used for the induction of shock) on CTA. Rats were sensitized to ovalbumin and subjected to a conditioning trial in which the conditioned stimulus (CS; saccharin solution given orally) signaled the presentation of the unconditioned stimulus (US; shocking doses of ovalbumin ranging from 0.5 to 3 mg given intraperitoneally). Behavioral signs, hematocrit, and rectal temperature were used for evaluation of anaphylactic shock. Twenty-four hours after the conditioning trial, rats were subjected to a two-bottle preference test between saccharin solution and water. Multiple regression statistical analysis revealed significant correlations among saccharin preference ratio, dose of antigen used for the induction of shock, behavioral signs of shock, rise in hematocrit, and fall in rectal temperature. A dose-dependent relation among saccharin preference ratio and physiological indicators of shock suggests that conditioned anaphylactic shock-induced avoidance behavior is functionally related to homeostatic factors involved in immune reactivity.

References (20)

There are more references available in the full text version of this article.

Cited by (22)

  • Applications and limitations of behaviorally conditioned immunopharmacological responses

    2017, Neurobiology of Learning and Memory
    Citation Excerpt :

    Additionally, a number of studies aimed to investigate conditioning effects of asthma-like symptoms, or histamine release. Results impressively indicate that mast cell functions are also responsive to behavioral conditioning paradigms (Djuric, Markovic, Lazarevic, & Jankovic, 1988; Irie, Maeda, & Nagata, 2001; Irie, Nagata, & Endo, 2002, 2004). Moreover, in healthy human volunteers proof-of-principle studies have demonstrated that conditioning or learned placebo responses can modulate peripheral immune responses, such as lymphocyte functions and cytokine production (Ader & Cohen, 1975; Goebel, Meykadeh, Kou, Schedlowski, & Hengge, 2008; Sabbioni et al., 1997; Schedlowski & Pacheco-Lopez, 2010; Wirth et al., 2011), as well as neuroendocrine functions, like release of glucocorticoids and growth hormones (Benedetti et al., 2003).

  • The learned immune response: Pavlov and beyond

    2010, Brain, Behavior, and Immunity
    Citation Excerpt :

    More recently, a conditioned reduction in disease severity in mice with experimental autoimmune encephalomyelitis was reported following conditioning with saccharin taste (CS) and alpha lipoic acid (US) (Jones et al., 2008). A series of studies addressed behavioral conditioning of asthma-like symptoms, anaphylactic shock (Djuric et al., 1988; Noelpp and Noelpp-Eschenhagen, 1951a–c; Palermo-Neto and Guimarães, 2000) or histamine release (Irie et al., 2001, 2002, 2004; Peeke et al., 1987). These experiments indicate that especially mast cell function (Marone et al., 2003) is responsive to conditioning protocols.

  • Behaviorally conditioned enhancement of immune responses

    2007, Psychoneuroimmunology, Two-Volume Set
  • Murine taste-immune associative learning

    2006, Brain, Behavior, and Immunity
View all citing articles on Scopus

This work was supported by the Republic of Serbia Research Fund, Belgrade.

View full text