Original contributionFree radical formation and DNA strand breakage during metabolism of diaziquone by NAD(P)H quinone-acceptor oxidoreductase (DT-diaphorase) and NADPH cytochrome c reductase☆
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2016, Chemico-Biological InteractionsDiaziridinylbenzoquinones
2004, Methods in EnzymologyCitation Excerpt :These DBQs have relatively high (more positive) E[Q⧸Q•−] and E[Q, 2H+⧸QH2] values, and hence they can also be reduced and activated by other cellular components such as glutathione (see following text), ascorbate and even NAD(P)H.41,42 Quinones can be reduced by a variety of one-electron reducing enzymes including NADPH:cytochrome P450 reductase,42,49,50 NADH:cytochrome b5 reductase51 and xanthine oxidase.40,52 They are also reduced by the two electron reducing enzymes, DTD26–29 and xanthine dehydrogenase.53
Cytotoxicity of RH1 and related aziridinylbenzoquinones: Involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress
2003, Archives of Biochemistry and BiophysicsMitochondrial damage prior to apoptosis in furanonaphthoquinone treated lung cancer cells
2003, Cancer Detection and PreventionInvolvement of NADPH: Cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species
2001, Biochemical PharmacologyCitation Excerpt :DNA damage was quantified using a laser densitometer. In order to account for the differential binding capacity of ethidium bromide with supercoiled plasmid compared with open circular and linear forms, a correction factor of 1.22 was applied to the supercoiled form [26]. Reproducible ESR spectra were obtained following aerobic incubation of EO9 with NADPH and NADPH: cytochrome P450 reductase.
Trace detection of hydroxyl radicals during the redox cycling of low concentrations of diaziquone: A new approach
2000, Free Radical Biology and Medicine
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Supported by PHS grant CA33681 awarded by the National Cancer Institute, DHHS.