GABAA receptor channels: from subunits to functional entities
References (50)
- et al.
γ-Aminobutyric Acid Type-A Receptor Point Mutation Increases the Affinity of Compounds for the Benzodiazepine Site
- et al.
Multiple Distinct Subunits of the 7-Aminobutyric Acid-A Receptor Protein Show Different Ligand-Binding Affinities
Mol Pharmacol
(1990) - et al.
Conserved Organization of y-Aminobutyric AcidA Receptor Genes-Cloning and Analysis of the Chicken β4-Sub-unit Gene
J Neurochem
(1991) - et al.
Type I and Type II GABAA-Benzodiazepine Receptors Produced in Transfected Cells
Science
(1989) - et al.
The y2 Subunit is an Integral Component of the 7-Aminobutyric AcidA Receptor but the al Polypeptide is the Principal Site of the Agonist Benzodiazepine Photoaffinity Labeling Reaction
J Biol Chem
(1990) - et al.
Functional and Molecular Distinction Between Recombinant Rat GABAA Receptor Subtypes by Zn2+
Neuron
(1990) - et al.
Another Mechanism for Creating Diversity in Y-Aminobutyric Type A Receptors: RNA Splicing Directs Expression of Two Forms of γ2-Sub-unit, One of which Contains a Protein Kinase C Phosphorylation Site
- et al.
Generation of Two Forms of the y-Aminobutyric AcidA Receptor y2-Subunit in Mice by Alternative Splicing
J Neurochem
(1991) - et al.
Differential Localization of Two Alternatively Spliced GABAA Receptor y2Subunit mRNAs in the Chick Brain
Eur J Neurosci
(1992) - et al.
Ethanol Sensitivity of the GABAA Receptor Expressed in Xenopus Oocytes Requires 8 Amino Acids Contained in the γ2L Subunit
Neuron
(1991)
Distribution of the GABAA Receptor al and 72 Subunit mRNAs in Chick Brain
Neurosci Lett
More than one Alpha Variant May Exist in a GABAA/Benzodiazepine Receptor Complex
J Receptor Res
Quantal Analysis of Inhibitory Transmission in the Dentate Gyros of Rat Hippocampal Slices: a Patch-Clamp Study
J Physiol
GABA: an Excitatory Transmitter in Early Postnatal Life
Trends Neurosci
Control of Postsynaptic Cat + Influx in Developing Neocortex by Excitatory and Inhibitory Neurotransmitters
Neuron
Expression Patterns of GABAA Receptor Subtypes in Developing Hippocampal Neurons
Neuron
Sequence of a Functional Invertebrate GABAA Receptor Subunit which can Form a Chimeric Receptor with a Vertebrate a Subunit
EMBO J
Mechanism of Anion Permeation Through Channels Gated by Glycine and YAminobutyric Acid in Mouse Cultured Spinal Neurones
J Pbysiol
Postsynaptic Fall in Intracellular pH Induced by GAGA-Activated Bicarbonate Conductance
Nature
Stress Induced Elevations of y-Aminobutyric Acid Type A ReceptorActive Steroids in the Rat Brain
γ-Aminobutyric AcidA Receptor Complexes in Rat Frontal Cortex and Spinal Cord Show Differential Responses to Steroid Modulation
Mol Pharmacol
The GABAA Receptor Family: Molecular and Functional Diversity
Multiple Benzodiazepine Receptors: No Reason for Anxiety
Trends Pbarmacol Sci
A Single Hlstidine in GABAA Receptors is Essential for Benzodiazepine Agonist Binding
J Biol Cbem
Cloning, Pharmacological Characteristics and Expression Pattern of the Rat GABAA Receptor a4 Subunit
FEBS Lett
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Shisa reduces the sensitivity of homomeric RDL channel to GABA in the two-spotted spider mite, Tetranychus urticae Koch
2023, Pesticide Biochemistry and PhysiologyArtesunate restores the levels of inhibitory synapse proteins and reduces amyloid-β and C-terminal fragments (CTFs) of the amyloid precursor protein in an AD-mouse model
2021, Molecular and Cellular NeuroscienceCitation Excerpt :Parallel to studies evidencing abnormal levels of gephyrin in post-mortem human AD-brains (Agarwal et al., 2008; Hales et al., 2013) we reported previously an evident decrease in the protein levels of both gephyrin, the main organizer of inhibitory synapses and the postsynaptic γ2-GABAA-receptor subunit in hippocampal subregions of 12-month-old double transgenic mice which co-express the Swedish mutated form of the human APP (APPswe) and at L166P mutated human presenilin 1 (PS1) genes (APP-PS1) (Kiss et al., 2016). The pentameric GABAARs and glycine receptors (GlyRs) formed by the co-assembly of different subunit types are responsible for the inhibition and modulation of the fast synaptic transmission in the central nervous system (Wisden and Seeburg, 1992; Kasaragod and Schindelin, 2019). A subset of GABAARs are thought to be anchored at postsynaptic membrane specializations by the multifunctional scaffolding protein gephyrin (Kneussel et al., 1999).
Systemic screening identifies GABRD, a subunit gene of GABAA receptor as a prognostic marker in adult IDH wild-type diffuse low-grade glioma
2019, Biomedicine and PharmacotherapyUnsupervised excitation: GABAergic dysfunctions in Alzheimer's disease
2019, Brain ResearchCitation Excerpt :However, the most frequent pentamers found in GABAARs are 2 α:2β:1 γ. Other combinations can also be found but are present in different brain regions (Wisden and Seeburg, 1992). Metabotropic GABABRs (GABAB1 and GABAB2) are G-protein coupled receptors that connect to the classical signal transduction machineries.