GABAA receptor channels: from subunits to functional entities

https://doi.org/10.1016/0959-4388(92)90113-YGet rights and content

Abstract

GABAA receptor channels mediate postsynaptic inhibition. The functional diversity of these receptors rests on differences in subunit composition and on a large repertoire of subunits. Subunit expression patterns in the brain have been found to predict in vivo compositions of GABAA receptors. In addition, molecular determinants underlying the differential binding properties of allosteric ligands to receptor subtypes have been identified.

References (50)

  • T.A. Glencorse et al.

    Distribution of the GABAA Receptor al and 72 Subunit mRNAs in Chick Brain

    Neurosci Lett

    (1991)
  • H. Lüddens et al.

    More than one Alpha Variant May Exist in a GABAA/Benzodiazepine Receptor Complex

    J Receptor Res

    (1991)
  • F.A. Edwards et al.

    Quantal Analysis of Inhibitory Transmission in the Dentate Gyros of Rat Hippocampal Slices: a Patch-Clamp Study

    J Physiol

    (1990)
  • E. Cherubim et al.

    GABA: an Excitatory Transmitter in Early Postnatal Life

    Trends Neurosci

    (1991)
  • R. Yuste et al.

    Control of Postsynaptic Cat + Influx in Developing Neocortex by Excitatory and Inhibitory Neurotransmitters

    Neuron

    (1991)
  • I. Killisch et al.

    Expression Patterns of GABAA Receptor Subtypes in Developing Hippocampal Neurons

    Neuron

    (1991)
  • R.J. Harvey et al.

    Sequence of a Functional Invertebrate GABAA Receptor Subunit which can Form a Chimeric Receptor with a Vertebrate a Subunit

    EMBO J

    (1991)
  • J. Bormann et al.

    Mechanism of Anion Permeation Through Channels Gated by Glycine and YAminobutyric Acid in Mouse Cultured Spinal Neurones

    J Pbysiol

    (1987)
  • K. Kaila et al.

    Postsynaptic Fall in Intracellular pH Induced by GAGA-Activated Bicarbonate Conductance

    Nature

    (1987)
  • R.H. Purdy et al.

    Stress Induced Elevations of y-Aminobutyric Acid Type A ReceptorActive Steroids in the Rat Brain

  • K.W. Gee et al.

    γ-Aminobutyric AcidA Receptor Complexes in Rat Frontal Cortex and Spinal Cord Show Differential Responses to Steroid Modulation

    Mol Pharmacol

    (1991)
  • P.H. Seeburg et al.

    The GABAA Receptor Family: Molecular and Functional Diversity

  • A. Doble et al.

    Multiple Benzodiazepine Receptors: No Reason for Anxiety

    Trends Pbarmacol Sci

    (1992)
  • H.A. Wieland et al.

    A Single Hlstidine in GABAA Receptors is Essential for Benzodiazepine Agonist Binding

    J Biol Cbem

    (1992)
  • W. Wisden et al.

    Cloning, Pharmacological Characteristics and Expression Pattern of the Rat GABAA Receptor a4 Subunit

    FEBS Lett

    (1991)
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