Biochemical and Biophysical Research Communications
Identification and characterization of a new binding site for angiotensin II in mouse neuroblastoma neuro-2A cells
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2018, Nephrology and Fluid/Electrolyte Physiology: Neonatology Questions and ControversiesNew and old roles of the peripheral and brain renin–angiotensin–aldosterone system (RAAS): Focus on cardiovascular and neurological diseases
2017, International Journal of CardiologyCitation Excerpt :The AT2 activation, instead, seems determine a protective role in the RAAS activation and induce anti-inflammatory and anti-fibrotic effects [9]. The recent discovery of nonAT1nonAT2 receptors, initially found in mouse neuroblastoma cells [11], seems to suggest that these receptors are able to modulate the binding of AII to the AT1 receptor. The scientific foundation on this hypothesis lies in the discovery of a novel nonAT1nonAT2 binding site for AII/angiotensin III (AIII) that mediates this activity.
Presence of functional angiotensin II receptor and angiotensin converting enzyme in the aorta of the snake Bothrops jararaca
2012, Life SciencesCitation Excerpt :The AT2 has been implicated in the hearing process and vascular injury, and it has an antiproliferative function (De Gasparo et al., 2000; Lemarié and Schiffrin, 2010), in contrast to the AT1, which stimulates cell growth. Additional Ang II receptor sites, not characterized as AT1 or AT2 receptors based on their pharmacological profile, have been identified in cells/tissues as neuroblastoma, heart, adrenal, brain or liver from vertebrate including rodents (Chaki and Inagami, 1992; De Oliveira et al., 1995), amphibians (Aiyar et al., 1994; Bergsma et al., 1993; Sandberg et al., 1991), birds (Brun et al., 2001; Kempf et al., 1996; Murphy et al., 1993) and fishes (Olivares-Reyes et al., 1997). This receptor has high affinity for the Ang II, and low affinity for the selective AT1 and AT2 receptor antagonists.
Renal Modulation: The Renin-Angiotensin-Aldosterone System
2012, Nephrology and Fluid/Electrolyte Physiology: Neonatology Questions and Controversies Expert ConsultRenal Modulation: The Renin-Angiotensin-Aldosterone System
2012, Nephrology and Fluid/Electrolyte PhysiologyRenal Modulation: The Renin-Angiotensin-Aldosterone System (RAAS)
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