Alternative transcripts of the rat and human dopamine D3 receptor

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A cDNA for the rat dopamine D3 receptor containing a 113 bp deletion has been isolated. The segment deleted, encompassing the first extracellular loop and third transmembrane domain, alters the reading frame, introducing 19 amino acids not found in the full length receptor followed by a premature stop codon. This novel mRNA encodes a 109 amino acid protein containing two putative tranmembrane domains. A similar variant cDNA for the human D3 receptor has also been identified.

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    The D3nf probe spans each side of, but omits, the missing 98 base pair region present in D3, and is as follows: 5′-CTG GGT GGC CTT CTT CTC TCG AAG TGG TAC T CAA GGA GTT CCG AGT CC-3′. Of the seven known D3 splice variants, our D3 receptor probe sequence should detect both full-length and short (D3S) D3 receptor variants, as well as the splice variants O2-del [22] and RD3in [23], while avoiding D3nf [24,25], TM3-del/D3R-del [22,26] and TM4-del [27]. A 48-base probe that is not complementary to any rat sequence (5′ AAT ACA CCG AGC GGT ACT CGA GGT GGT ACA TGT TGG GGT AGT AAA TAA 3′) was used as a control.

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