Elsevier

Brain Research

Volume 832, Issues 1–2, 19 June 1999, Pages 168-170
Brain Research

Short communication
Orphanin FQ/nociceptin blocks acquisition of morphine place preference

https://doi.org/10.1016/S0006-8993(99)01425-0Get rights and content

Abstract

Orphanin FQ/nociceptin (OFQ/N) suppresses the activity of the dopaminergic mesolimbic reward pathway yet reportedly fails to produce conditioned place aversion or preference. The present study sought to determine if this peptide could attenuate the development of morphine place preference. Male rats were administered OFQ/N (3 to 30 nmol intracerebroventricularly) during the induction of morphine (3 mg/kg subcutaneously) place preference. Animals receiving 3 or 10 nmol (but not 30 nmol) OFQ/N showed significant reductions in the development of place preference to morphine.

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Acknowledgements

We gratefully acknowledge the assistance of Mr. Jeff Fein for synthesis of OFQ/N and Dr. Kym Faull for mass spectrometric analysis. This work was supported by NIDA #DA05010 and #DA09359.

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