A study of “total therapy” of acute lymphocyticleukemia in children,††

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A study was designed to test the hypothesis that, following induction of remission and an intensive short-term, high-dosage phase of treatment, continuous maintenance chemotherapy with the use of a combination of 4 antileukemic agents concurrently in conjunction with radiotherapy to the entire craniospinal axis would produce prolonged complete remission in patients with previously untreated acute lymphocytic leukemia. The intensive systemic administration of antileukemic agents resulted in longer complete remissions than described in other studies, and survival was at least equal to that obtained with sequential use of these agents.

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Presented in part before the Fifty-Seventh Annual Meeting of the American Association for Cancer Research, Denver, Colo., May 26, 1966.

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Supported by Research Grants CA 07594,CA 05176, and CA 08480 from the National Cancer Institute, National Institutes of Health, Public health Service, and by the American Lebanese Syrian Associated Charities.

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National Cancer Institute, National Institutes ofHealth, Public Health Service. Present address, Department of Pediatrics, University of Tennessee College of Medicine, 860 Madison Ave., Memphis, Tenn. 38103.

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