Properties, regulation and function of muscarinic receptorSphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors
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Sphingosine-1-phosphate (S1P) activates STAT3 to protect against de novo acute heart failure (AHF)
2018, Life SciencesCitation Excerpt :It is also highly possible that S1P may act as an intracellular agent without the necessity for receptor binding. Indeed, intracellular endogenous S1P is known to be involved in the regulation of cell survival paths, ion channels and calcium activity within the cell, independently of its specific cell binding receptors [18,23]. It is also unclear how exogenous S1P may interact the endogenous levels of S1P present within the cell.
Sexual dimorphism of metabolic and vascular dysfunction in aged mice and those lacking the sphingosine 1-phosphate receptor 3
2017, Experimental GerontologyCitation Excerpt :Another mechanism leading to vasodilation that could be impacted in a sex-dependent manner in the aged is signaling by S1P downstream of the muscarinic-3 (M3) receptor. Methacholine activates sphingosine kinase through M3 (Mulders et al., 2009; Pfaff et al., 2005; van Koppen et al., 2001) and loss of S1PR3 abolishes dilation of aortic (large conduit) arteries (Nofer et al., 2004). These results indicate that methacholine-induced vasodilation in mesenteric arteries could also depend on S1P signaling.
Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells
2009, International Journal of Biochemistry and Cell BiologySphingosine kinase/sphingosine 1-phosphate signalling in central nervous system
2009, Cellular SignallingK6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular CA<sup>2+</sup> signaling
2008, Journal of Investigative Dermatology