Pharmacology letter Accelerated communicationTramadol induces antidepressant-type effects in mice
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Cited by (90)
The plausible mechanisms of tramadol for treatment of COVID-19
2021, Medical HypothesesCitation Excerpt :It can bind to μ-opioid receptors and inhibit norepinephrine and serotonin reuptake [20]. Through its capability to inhibit norepinephrine and serotonin reuptake, tramadol may possess antidepressant activity [18,39,40]. In this context, the antidepressant activities of tramadol may favor its indication for COVID-19 patients.
Involvement of NMDA receptors in the antidepressant-like effect of tramadol in the mouse forced swimming test
2017, Brain Research BulletinPanicolytic-like effect of tramadol is mediated by opioid receptors in the dorsal periaqueductal grey
2017, Behavioural Brain ResearchCitation Excerpt :A previous report showed that acute and systemic administration of tramadol, at the same dose and action time we used here, produced an antidepressant-like effect in mice in the tail suspension test [28]. Furthermore, some studies using animal models of depression showed that tramadol produced an antidepressant-like effect by itself [8,9,28–30], and potentiated the antidepressant-like effect of the SNRI (serotonin and noradrenaline reuptake inhibitor), venlafaxine [31]. Currently, antidepressants are considered the drugs of choice for the treatment of PD [32], although, they have some limitations, such as delay in the onset of the therapeutic effect and worsening of initial symptoms with increased anxiety [33].
Cortical excitability in tramadol dependent patients: A transcranial magnetic stimulation study
2016, Drug and Alcohol DependenceCitation Excerpt :It has a dual mechanism of action that includes both inhibition of norepinephrine and serotonin uptake and weak agonistic action on the μ-opioid receptor (Grond and Sablotzki, 2004). It is considered to be a CNS suppressant; however, some studies have indicated an activating effect of tramadol (Fox et al., 2009; Rojas-Corrales et al., 1998; Vaughan et al., 2000). Clinical studies reported tramadol to cause seizures even at recommended analgesic doses, while, experimental studies showed that convulsions only occur after high, toxic doses (Jang et al., 2010; Potschka et al., 2000; Raiger et al., 2012; Ryan and Isbister 2015).
Efficacy of tramadol–acetaminophen tablets in low back pain patients with depression
2015, Journal of Orthopaedic Science
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