Synergistic interaction between castanospermine and tacrolimus in a rat heart allograft model
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Cited by (13)
Synthesis and biological activity of diastereoisomeric octahydro-1H-indole-5,6,7-triols, analogues of castanospermine
2019, TetrahedronCitation Excerpt :Unfortunately, in all cases, low IC50 values were also measured for non-malignant mouse fibroblasts NiH 3T3 (Table 2). The final compounds 22 and 23 were screened for their α-mannosidase inhibitor activities [19] against recombinant Drosophila melanogaster Golgi (GMIIb), lysosomal (LManII) α-mannosidase and α-mannosidase from Canavalia ensiformis (JBMan). The obtained results are compiled in Table 3.
Contribution to the synthesis of polyhydroxylated indolizidines starting from sugar isothiocyanates
2016, Tetrahedron AsymmetryCitation Excerpt :In particular, the construction of the unnatural epimeric congeners and the other related structural analogues has stimulated extensive synthetic efforts because structural modifications in iminosugars based on the number, position and stereochemistry of the hydroxyl functionalities in the parent skeletons can induce significant changes in their activities.11 Our previous success with the total synthesis of biologically active α-substituted α-amino acid scaffolds12 from sugar templates suggested that the [3,3]-sigmatropic rearrangements on structurally appropriate allylic substrates effectively installed the CN bond. In continuation of our studies, we were interested in investigating the use of the rearranged products (5R)-2 and (5S)-2, which were effectively prepared on a multigram scale, for the general preparation of tri- and pentahydroxylated indolizidine alkaloids.
The effects of Castanospermine, an oligosaccharide processing inhibitor, on mononuclear/endothelial cell binding and the expression of cell adhesion molecules
2012, Transplant ImmunologyCitation Excerpt :There is a continuing need to improve the immunosuppressive agents used because of their toxicity which includes cancer [1], nephrotoxicity [2], diabetes mellitus [3] and infection [4]. Castanospermine (CAST), a glycosidase inhibitor, is a novel immunosuppressive agent that prolongs cardiac allograft survival [5], acts synergistically with tacrolimus [6], and alleviates experimental autoimmune encephalomyelitis (EAE) [7] and adjuvant induced polyarthritis [8]. It is relatively non-toxic in the rat [5].
Synthesis of castanospermine
2008, TetrahedronIndolizidine and quinolizidine alkaloids structure and bioactivity
2002, Studies in Natural Products ChemistryPolyhydroxylated alkaloids - Natural occurrence and therapeutic applications
2001, Phytochemistry